A retrospective specular microscopic study of 118 clear corneal grafts shows that the endothelium of these grafts is progressively destroyed during the two first years. The reduction of cellular density is rapid at the beginning of postoperative period, stabilizing after two years. The comparison of endothelial cellular density in fresh non selected grafts versus grafts preserved in culture seems to indicate a longer survival of preserved grafts. This study shows the utility of wide-field specular microscopy in the follow-up of clear corneal grafts. This technique furnishes useful information for postoperative management and long-term prognosis.
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