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The Cleveland Clinic experience of eosinophilic myocarditis in the setting of hypereosinophilic syndrome: demographics, cardiac imaging, and outcomes.
Cardiovasc Diagn Ther
December 2024
Section of Cardiovascular Imaging, Robert and Suzanne Tomsich Department of Cardiovascular Medicine, Sydell and Arnold Miller Family Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH, USA.
Background: Hypereosinophilic syndrome (HES) represents a group of disorders with eosinophil-mediated end-organ damage. Eosinophilic myocarditis (EM) represents cardiac involvement in HES. Data are limited regarding this rare condition.
View Article and Find Full Text PDFPediatric eosinophilic granulomatosis with polyangiitis and intracardiac thrombus: A case report.
SAGE Open Med Case Rep
December 2024
Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic necrotizing vasculitis marked by eosinophilia and extravascular granulomas, predominantly affecting the respiratory tract. This report details a unique EGPA case in a 6-year-old girl with extensive cardiac involvement, featuring an atypical intracardiac mass suggestive of endomyocardial fibrosis and a concomitant thrombus. The clinical course unfolded in three phases: an initial prodrome with asthma; subsequent peripheral hypereosinophilia; and ultimately systemic vasculitis.
View Article and Find Full Text PDFA Case of Eosinophilic Infiltration of the Right Heart: Diagnostic and Management Considerations.
Heart Views
October 2024
Department of Cardiology, Royal Lancaster Infirmary, Lancaster, United Kingdom.
Loeffler first described "fibroplastic parietal endocarditis with blood eosinophilia" in 1936. This we now know refers to the most common cardiac manifestation of an uncommon condition, the so-called hypereosinophilic syndromes. This condition typically results in a restrictive cardiomyopathy affecting the left heart, but here, we present an unusual case of a 65-year-old woman with chronic hypereosinophilia of at least 2 years, who presented with right heart failure as a result of eosinophilic endomyocardial infiltration of her right ventricle.
View Article and Find Full Text PDFCardiac Abnormalities in Hypereosinophilic Syndromes.
Arq Bras Cardiol
October 2024
Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP - Brasil.
Article Synopsis
- Hypereosinophilia (HE) is characterized by an eosinophil count over 1500 cells/microL in blood tests, confirmed by either blood tests or high eosinophil percentages in bone marrow samples. Hypereosinophilic syndrome (HES) involves organ damage due to eosinophils and can be classified as primary, secondary, or idiopathic.
- Cardiac issues occur in 5% of acute cases and 20% of chronic cases of HES, presenting symptoms like heart failure and arrhythmias, but the severity of heart problems isn't always proportional to eosinophil levels.
- Diagnosis of cardiac involvement relies on advanced imaging techniques, particularly
Fulminant eosinophilic myocarditis and doxycycline administration: a case report.
Eur Heart J Case Rep
November 2024
Department of Cardiology, Dijon Bourgogne University Hospital, France.
Background: Eosinophilic myocarditis is a life-threatening condition with a heterogeneous clinical presentation and aetiology. Cases of drug-induced or parasitic myocarditis have been reported but there is scant literature on the involvement of treatments, such as doxycycline, and eosinophil degranulation due to parasitic lysis.
Case Summary: Here, we report the case of a 59-year-old man without a relevant past medical history who developed a skin rash with hepatic cytolysis and mild eosinophilia.
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