Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Update on regulation of GHRH and its actions on GH secretion in health and disease.
Rev Endocr Metab Disord
January 2025
Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, IL, USA.
This review focuses on our current understanding of how growth hormone releasing hormone (GHRH): 1) stimulates GH release and synthesis from pituitary growth hormone (GH)-producing cells (somatotropes), 2) drives somatotrope proliferation, 3) is negatively regulated by somatostatin (SST), GH and IGF1, 4) is altered throughout lifespan and in response to metabolic challenges, and 5) analogues can be used clinically to treat conditions of GH excess or deficiency. Although a large body of early work provides an underpinning for our current understanding of GHRH, this review specifically highlights more recent work that was made possible by state-of-the-art analytical tools, receptor-specific agonists and antagonists, high-resolution in vivo and ex vivo imaging and the development of tissue (cell) -specific ablation mouse models, to paint a more detailed picture of the regulation and actions of GHRH.
View Article and Find Full Text PDFArticle Synopsis
- This review examines the causes of headaches in patients with acromegaly and how various treatments for the condition affect headache symptoms.
- Headaches occur in 30-70% of acromegaly patients due to factors such as the tumor itself, hormonal changes, and other underlying issues, necessitating careful diagnosis and management.
- Despite treatments like surgery and medication normalizing hormone levels, headaches may still persist, highlighting the need for specialized headache management for these patients.
Expression of the apelin system in the porcine pituitary during the oestrous cycle and early pregnancy and the effect of apelin on LH and FSH secretion.
Theriogenology
December 2024
Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-719, Olsztyn, Poland. Electronic address:
Reproductive success requires considerable energy investment. Research has shown that some adipokines, i.e.
View Article and Find Full Text PDFAssociation between IGF-1 and IGFBPs in Blood and Follicular Fluid in Dairy Cows Under Field Conditions.
Animals (Basel)
August 2024
Veterinary-Endocrinology and Laboratory Diagnostics, Clinic for Cattle, University of Veterinary Medicine Hannover, Foundation, 30173 Hannover, Germany.
Insulin-like growth factor 1 (IGF-1) regulates dairy cow reproduction, while the paracrine IGF system locally influences fertility. In both systems, IGF-1 bioactivity is regulated through binding proteins (IGFBPs) inhibiting IGF-1 binding to its receptor (IGF1R). This study aimed to investigate a possible transfer between this endocrine and paracrine system.
View Article and Find Full Text PDFDynamic changes in insulin-like growth factor binding protein expression occur between embryonic and early post-hatch development in broiler chickens.
Poult Sci
November 2024
Department of Poultry Science, University of Georgia, Athens, GA 30602, USA. Electronic address:
Somatotropic gene expression has been altered by genetic selection, and developmental changes in insulin-like growth factor (IGF) and IGF binding protein (IGFBP) expression may contribute to rapid growth and muscle accretion in commercial broilers. The objective of this study was to evaluate changes in somatotropic axis activity between embryonic day (e) 12 and post-hatch day (d) 21. Liver and breast muscle (pectoralis major) were collected to measure gene expression, and blood was collected post-hatch to measure circulating IGFs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!