An unusual case characterized by autoimmune hemolytic anemia, fever, polyarthralgias, was developed after PUVAtherapy. Investigation revealed ESR accelerated, complement consumption, diminished levels of C4 and C3, high levels of ANA were detected. In recent years, lupus erythematosus like syndrome was related with photosensitivity provoked by PUVA-therapy. Long-wave ultraviolet light was consider a precipitating factor in the development of autoimmune phenomena. On the contrary, in other researches suggests that PUVA induced alterations are not antigenic this discrepancy remains to be clarified. However this iatrogenic risk must be avoided with a clinical and serological controls.
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