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Temporal and spatial pattern of DNA damage in neurons following spinal cord Injury in mice.
J Biomed Sci
January 2025
Neurosciences, Biomedical Research Institute, Hasselt University, Agoralaan Building C, 3590, Diepenbeek, Belgium.
Background: Deficient DNA repair and excessive DNA damage contribute to neurodegenerative disease. However, the role of DNA damage and repair in spinal cord injury (SCI) is unclear. SCI, a debilitating disruption of the structural and biological network of the spinal cord, is characterized by oxidative stress.
View Article and Find Full Text PDFMagnetic resonance imaging and pathological findings of aortoiliac thromboembolism with a thoracic aortic mural thrombus in a Japanese Black calf.
J Vet Med Sci
January 2025
Joint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University.
A 24-day-old female Japanese Black calf presented a sudden paraplegia after a history of watery diarrhea. Antemortem magnetic resonance imaging confirmed the suspicion of thrombotic component in the abdominal aorta, without any spinal cord abnormality at the lumbar region. On necropsy, a massive thrombus occupied the lumen from the distal abdominal aorta to the bifurcation of the external iliac arteries.
View Article and Find Full Text PDFBRAF inhibitor monotherapy in BRAFV600E-mutated pediatric low-grade glioma: a single center's experience.
Front Oncol
January 2025
Department of Pediatrics, Children's Healthcare of Atlanta, Atlanta, GA, United States.
Background: Pediatric low-grade gliomas (pLGGs) have an overall survival of over 90%; however, patients harboring a BRAF alteration may have worse outcomes, particularly when treated with classic chemotherapy. Combined BRAF/MEK inhibition following incomplete resection demonstrated improved outcome in BRAF altered pLGG compared to combined carboplatin/vincristine chemotherapy and is now considered the standard FDA-approved treatment for this group of tumors. The aim herein was to investigate the efficacy and tolerability of single agent BRAF inhibitor treatment in BRAF altered pLGG.
View Article and Find Full Text PDFAcute intermittent hypoxia in spinal cord injury gait rehabilitation: a systematic review of randomized trials.
Neurol Sci
January 2025
Department of Physiotherapy, Middle East University, Airport Road, Amman, 11831, Jordan.
Background: Gait impairments are one of the popular consequences of spinal cord injury (SCI). Acute intermittent hypoxia (AIH) is an innovative treatment that has recently been used to enhance motor function in patients with neurological conditions. This review aims to examine the effects of AIH on gait post-SCI, verify who most likely would benefit from the treatment, and recognize the best treatment protocol, if possible.
View Article and Find Full Text PDFComparison of long-term clinical and radiologic outcomes of AperFix and fixed loop device fixation in anterior cruciate ligament reconstruction: A retrospective study.
Medicine (Baltimore)
January 2025
Department of Orthopaedics and Traumatology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey.
Anterior cruciate ligament reconstruction aims to improve knee stability and range of motion. The AperFix system consists of polymer components, and fixed-loop fixation is an established endoscopic technique. Our aim in this study was to compare the long-term clinical and radiological results of AperFix and fixed-loop fixation and to prove that the long-term results of the AperFix fixation method are at least as good as those of the fixed loop device.
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