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Interaural level difference sensitivity in neonatally deafened rats fitted with bilateral cochlear implants.
Sci Rep
December 2024
Neurobiological Research Laboratory, Section for Experimental and Clinical Otology, Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Medical Center - University of Freiburg, Killianst. 5, 79106, Freiburg im Breisgau, Germany.
Bilateral cochlear implant (CI) patients exhibit significant limitations in spatial hearing. Their ability to process interaural time differences (ITDs) is often impaired, while their ability to process interaural level differences (ILDs) remains comparatively good. Clinical studies aiming to identify the causes of these limitations are often plagued by confounds and ethical limitations.
View Article and Find Full Text PDFImpairment of neuromotor development and cognition associated with histopathological and neurochemical abnormalities in the cerebral cortex and striatum of glutaryl-CoA dehydrogenase deficient mice.
Neurochem Int
December 2024
PPG Ciências Biológicas: Bioquímica, Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, Brazil; Departamento de Medicina Interna, Faculdade de Medicina, UFRGS, Porto Alegre, Brazil; Serviço de Genética Médica, HCPA, Porto Alegre, Brazil. Electronic address:
Patients with glutaric acidemia type I (GA I) manifest motor and intellectual disabilities whose pathogenesis has been so far poorly explored. Therefore, we evaluated neuromotor and cognitive abilities, as well as histopathological and immunohistochemical features in the cerebral cortex and striatum of glutaryl-CoA dehydrogenase (GCDH) deficient knockout mice (Gcdh), a well-recognized model of GA I. The effects of a single intracerebroventricular glutaric acid (GA) injection in one-day-old pups on the same neurobehavioral and histopathological/immunohistochemical endpoints were also investigated.
View Article and Find Full Text PDFPriority order of neonatal colonization by a probiotic or pathogenic strain dictates the host response to experimental colitis.
Front Microbiol
August 2024
Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, Nový Hrádek, Czechia.
Article Synopsis
- The study investigates the impact of specific bacterial strains on inflammatory bowel disease (IBD) in early childhood, focusing on the probiotic Nissle 1917 and a pathogenic strain O6:K13:H1.
- Nissle 1917 shows potential to positively modulate the immune response and protect against the effects of the harmful strain when colonized early in the intestinal environment of mice.
- The findings suggest that the timing of bacterial colonization is crucial for influencing immune response and gut health, which may have implications for treatment and management of IBD in children.
Prostaglandin E2 Induces YAP1 and Agrin Through EP4 in Neonatally-Derived Islet-1+ Stem Cells.
Stem Cells Dev
September 2024
Department of Pathology and Human Anatomy, Loma Linda University School of Medicine, Loma Linda, California, USA.
Prostaglandin E2 (PGE2) has recently gained attention in the field of regenerative medicine because of the beneficial effects of this molecule on stem cell proliferation and migration. Furthermore, PGE2 has the ability to mitigate immune rejection and fibrosis. In the colon and kidney, PGE2 induces YAP1, a transcription factor critical for cardiac regeneration.
View Article and Find Full Text PDFNeonatal testosterone voids sexually differentiated microglia morphology and behavior.
Front Endocrinol (Lausanne)
March 2023
Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
The involvement of immunity in psychiatric disorders, such as anxiety, is typified by the morphologic adaptation of microglia, immune cells of the brain, to anxiogenic stimuli. We previously reported sexually differentiated microglia morphology in adult rodents, in brain locations implicated in anxiety, including the pre-frontal cortex. These physiologic differences likely drive sex-dependent patterns of microglia morphologic remodeling in response to varied stress conditions in different periods of life, that correlate with sex-dependent behavioral adaptation to anxiogenic stimuli.
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