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Pulmonary malakoplakia due to Prescottella (Rhodococcus) soli in a renal transplant recipient: First reported case.
Eur J Microbiol Immunol (Bp)
December 2024
1Department of Microbiology, NSW Health Pathology, John Hunter Hospital, New Lambton Heights, NSW, Australia.
Prescottella (Rhodococcus) soli is a soil-dwelling organism not previously thought to be pathogenic in humans. We discuss the case of a 78-year-old male renal transplant recipient presenting with respiratory symptoms and multiple pulmonary nodules, found to be pulmonary malakoplakia secondary to infection with Prescottella (Rhodococcus) soli. Treatment was commenced with vancomycin, meropenem and azithromycin for an induction period of two weeks and continued with indefinite oral moxifloxacin and azithromycin with significant clinical improvement.
View Article and Find Full Text PDFA very complicated UTI: malakoplakia following E. coli urinary tract infection.
BMC Nephrol
June 2024
Department of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Malakoplakia is a rare inflammatory disorder believed to result from a defect in macrophage phagocytic function triggering a granulomatous reaction. It can present with genitourinary, gastrointestinal, or cutaneous manifestations in immunocompromised or, less commonly, immunocompetent hosts. We describe a case of renal malakoplakia in a young, otherwise healthy patient presenting with nephromegaly and sepsis following an E.
View Article and Find Full Text PDFCase report: Prostatic malakoplakia: a rare disease that has a profile mimicking prostate cancer.
Front Oncol
April 2024
Department of Medical Ultrasound, West China Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- - Prostatic malakoplakia (PMP) is a rare inflammatory condition that can be misdiagnosed through imaging, leading to unnecessary biopsies; this study aimed to summarize the imaging features of PMP in five patients.
- - All patients, aged 58 to 74 years, underwent ultrasound-guided prostate biopsies which confirmed PMP and excluded prostate cancer; imaging showed high signal lesions on T1-weighted MRI and abnormal prostate morphology on ultrasound.
- - While PSA levels, MRI, and ultrasound aren't specific indicators of PMP, a history of co-infections could aid in accurate diagnosis and prevent unnecessary biopsies.
Bifocal malakoplakia in a patient living with HIV: case report.
AIDS Res Ther
January 2024
Pathology department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Background: Malakoplakia is a rare chronic granulomatous disease characterized by the presence of Michaelis-Gutmann bodies (MGBs) within histiocytic aggregates. It predominantly affects immunocompromised individuals, including those living with Human Immunodeficiency Virus (HIV).
Case Presentation: We present a unique case of bifocal malakoplakia in a 49-year-old man, previously with Coronavirus disease 2019 (COVID-19) and HIV positive, presented with respiratory symptoms, weight loss, and lymphadenopathy.
Intestinal Lesions Due to Rhodococcus equi in a Patient With Advanced Retroviral Disease and Pulmonary Infection: A Case of Colonic Malakoplakia.
Cureus
July 2023
Department of Infectious and Tropical Diseases, Azienda Ospedaliera Universitaria Policlinico (AOUP) "Paolo Giaccone", Palermo, ITA.
In humans, () is a zoonotic infection usually involving immunocompromised subjects, only rarely affecting immunocompetent subjects. Herein, we describe an infection in a 50-year-old Russian man with acquired immune deficiency syndrome (AIDS) who presented with pulmonary cavitary lesions and clinical manifestation of colonic malakoplakia. A colonoscopy examination showed ulceration and mucosal erosion, and the histological findings confirmed the colonic malakoplakia.
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