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Maternal di(2-ethylhexyl) phthalate exposure increases the risk of congenital heart disease in mice offspring.
Pediatr Res
March 2025
Pediatric Heart Center, NHC Key Laboratory of Neonatal Diseases, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.
Abstrct: BACKGROUD: Epidemiological data suggest that maternal occupational exposure to mixed phthalates comprising di(2-ethylhexyl) phthalate (DEHP) increases the risk of congenital heart disease (CHD). In this study, we used mice as an animal model to validate impact of first-trimester DEHP exposure on the risk of CHD in offspring, to elucidate the possible mechanisms and to provide a potential feasible intervention.
Methods And Results: Eight-week-old C57BL/6J pregnant mice were randomly divided into standard and DEHP diet groups.
Objective: This study reports on patent ductus arteriosus (PDA) therapy trends across the Children's Hospital Neonatal Consortium.
Study Design: We performed a 12-year (2011-2022) retrospective study of premature infants (< 33 weeks) with a PDA. We utilized descriptive statistics to compare demographic, inpatient, and discharge characteristics in 3-year epochs.
Isolated Congenital Vertebral Anomaly and Sprengel's Deformity in a WBP11 Pathogenic Variant.
Eur J Med Genet
March 2025
Department of Rehabilitation Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. Electronic address:
The pathogenic variant of WBP11 has been known as one of the various genetic causes of VACTERL syndrome. VACTERL syndrome is usually diagnosed with at least three clinical features of vertebral, heart, tracheal, esophageal, kidney, and limb anomalies. So far, only four WBP11 pathogenic variants have been documented from 13 patients, first and latest described in 2020.
View Article and Find Full Text PDFRelationship of pulmonary artery size and venovenous collaterals during staged single ventricle reconstruction and their impact on outcomes after fontan procedure.
Interdiscip Cardiovasc Thorac Surg
March 2025
Department of Congenital and Pediatric Heart Surgery, German Heart Center Munich, University Hospital of Technische Universität München, Munich, Germany, Division of Congenital and Pediatric Heart Surgery, University Hospital of Munich, Ludwig-Maximilians-Universität München, Munich, Germany, Europäisches Kinderherzzentrum München, Munich, Germany.
Objectives: This study aimed to evaluate the relationship between pulmonary artery size and venovenous collaterals during staged single ventricle reconstruction.
Methods: Patients who underwent staged Fontan palliation between 2003 and 2023 were reviewed. The relationship between the pulmonary artery index and the development of venovenous collaterals was determined.
Global, regional, and national burden of congenital heart disease, 1990-2021: a systematic analysis for the global burden of disease study 2021.
Eur J Pediatr
March 2025
Department of Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710004, China.
Unlabelled: Congenital heart disease (CHD) is a major birth defect characterized by structural and functional heart abnormalities. This study provides updated estimates of CHD prevalence, mortality, and disability using the Global Burden of Disease (GBD) 2021 database. We examined the age-standardized rates of CHD prevalence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021, stratified by gender, age group, and region.
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