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Associations Between the Neural Stress Response and Symptoms of Anxiety and Depression.
J Neurosci Res
January 2025
Department of Psychology, University of Regensburg, Regensburg, Germany.
Anxiety and depression disorders show high prevalence rates, and stress is a significant risk factor for both. However, studies investigating the interplay between anxiety, depression, and stress regulation in the brain are scarce. The present manuscript included 124 law students from the LawSTRESS project.
View Article and Find Full Text PDFConstruct validity, responsiveness, and interpretability of the Spinal Cord Injury Functional Ambulation Inventory (SCI-FAI).
J Spinal Cord Med
January 2025
Department of Physical Therapy, Ibaraki Prefectural University of Health Sciences, Ibaraki, Japan.
Objective: We investigated the construct validity, responsiveness, and interpretability of the Spinal Cord Injury Functional Ambulation Inventory (SCI-FAI) to determine its usefulness in measuring the functional level of gait.
Patients And Methods: This was a prospective observational study following the checklist of the Consensus-Based Standards for Selecting Health Measurement Instruments. The SCI-FAI consists of three items: Gait Parameter, Assistive Devices, and Temporal.
Design of Fluorinated Peptides as Biotransformed Urinalysis Biomarkers for Non-Invasive Diagnosis and Treatment of Liver Injury through Enzyme Directed Kinetics.
Adv Mater
January 2025
State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, China.
Urinalysis, as a non-invasive and efficient diagnostic method, is very important but faces great challenges due to the complex compositions of urine and limited naturally occurring biomarkers for diseases. Herein, by leveraging the intrinsic absence of endogenous fluorinated interference, a strategy with the enzymatically activated assembly of synthetic fluorinated peptide for cholestatic liver injury (CLI) diagnosis and treatment through F nuclear magnetic resonance (NMR) urinalysis and efficient drug retention is developed. Specifically, alkaline phosphatase (ALP), overexpressed in the liver of CLI mice, triggers the assembly of fluorinated peptide, thus, directing the traffic and dynamic distribution of the synthetic biomarkers after administration, whereas CLI mice display much slower clearance of peptides through urine as compared with healthy counterparts.
View Article and Find Full Text PDFCharacterization of dynamic features in the walking videos of patients with adolescent idiopathic scoliosis based on moving entropy.
Chaos
January 2025
College of Science, Civil Aviation University of China, Tianjin 300300, China.
Adolescent idiopathic scoliosis (AIS), which typically occurs in patients between the ages of 10 and 18, can be caused by a variety of reasons, and no definitive cause has been found. Early diagnosis of AIS or timely recognition of progression is crucial for the prevention of spinal deformity and the reduction of the risk of surgery or postponement. However, it remains a significant challenge.
View Article and Find Full Text PDFSynchronization stability of epileptic brain network with higher-order interactions.
Chaos
January 2025
Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Generally, epilepsy is considered as abnormally enhanced neuronal excitability and synchronization. So far, previous studies on the synchronization of epileptic brain networks mainly focused on the synchronization strength, but the synchronization stability has not yet been explored as deserved. In this paper, we propose a novel idea to construct a hypergraph brain network (HGBN) based on phase synchronization.
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