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Clinical features and risk factors of invasive pulmonary aspergillosis in interstitial lung disease patients.
BMC Pulm Med
December 2024
Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.
Article Synopsis
- Invasive pulmonary aspergillosis (IPA) is increasingly common in patients with interstitial lung disease (ILD), leading to high mortality rates, prompting a study to analyze the clinical features and risk factors associated with IPA in these patients.
- The study evaluated 353 hospitalized ILD patients, identifying 58 cases of IPA, primarily characterized by symptoms like cough and dyspnea, and revealed key CT findings such as honeycombing and consolidation.
- Significant risk factors for IPA included lymphopenia and honeycombing, with a 90-day survival rate of 74.1% among patients treated with antifungal drugs.
[Allergic bronchopulmonary aspergillosis in a patient with diabetes mellitus as the only risk factor].
Rev Alerg Mex
September 2024
Servicio de Neumología y Cirugía de Tórax; Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México (UNAM), Tlalnepantla, Estado de México.
Article Synopsis
- Allergic bronchopulmonary aspergillosis is a rare immune response to the fungus Aspergillus fumigatus, leading to symptoms like lung inflammation and high eosinophil counts in the blood.
- A 42-year-old male with diabetes exhibited severe respiratory issues and was found to have high eosinophils and elevated IgE for the fungus; he was treated with oxygen, prednisone, and itraconazole, resulting in improvement.
- The condition can be deadly, especially in immunocompromised individuals; diabetic patients have a higher prevalence of fungal infections, with nearly 37% potentially affected compared to only 4.7% in non-diabetics.
Development of a Prognostic Nomogram for Nonneutropenic Invasive Pulmonary Aspergillosis Based on Machine Learning.
J Inflamm Res
November 2024
Department of Respiratory and Critical Care Medicine, Zhongshan City People's Hospital, Zhongshan, Guangdong Province, People's Republic of China.
Article Synopsis
- The study investigates the increasing incidence of invasive pulmonary aspergillosis (IPA) in nonneutropenic patients and aims to identify prognostic factors for better outcomes.
- It employs LASSO regression and multivariate Cox regression to analyze data from 210 hospitalized patients, identifying key predictive factors like age and comorbid conditions.
- A predictive nomogram model was developed, showing strong predictive performance and allowing for risk stratification into high and low-risk groups based on patient scores.
Enhancing antifungal treatment for chronic cavitary pulmonary aspergillosis through the addition of endobronchial valve therapy.
Respir Med Case Rep
September 2024
Service de Pneumologie et d'Oncologie Thoracique et Centre Constitutifs Maladies Pulmonaires Rares, Hôpital Tenon, APHP Sorbonne Université, Paris, France.
Article Synopsis
- This treatment led to a serious complication, chronic cavitary pulmonary aspergillosis and a complete left pneumothorax caused by an alveolar-pleural fistula from a ruptured lung cavity.
- After a prolonged drainage period without improvement, he received antifungal and endobronchial valve therapy, resulting in no more air leaks, re-expansion of the left lung, and closure of the aspergillosis cavitation.
A Diagnostic Dilemma: A Case of Complicated Pneumonia With Pyelonephritis and Subclinical Myocarditis.
Cureus
June 2024
Internal Medicine, Adesh Institute of Medical Science and Research, Bathinda, IND.
A 41-year-old woman presented with a 3.5-month history of fever, weakness, productive cough, and burning micturition along with generalized weakness and significant weight loss. Chest X-ray revealed bilateral infiltrates and bilateral pleural effusion, and the workup suggested community-acquired pneumonia (CAP).
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