Comparison of the specific features of the environment and human activities in aviation and space flights allows us to distinguish the major relations in the system man--vehicle--environment as related to their medical support. It is concluded that in the aviation flight the man-vehicle interaction plays the leading role while in the space flight the man-environment interaction comes to the foreground. Having in view these differences, medical and professional selection, prediction, medical monitoring and medical support of pilots and cosmonauts are discussed.
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