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Alginate-polylysine-alginate (APA) microencapsulated transgenic human amniotic epithelial cells ameliorate fibrosis in hypertrophic scars.
Inflamm Res
January 2025
Department of Burns and Cutaneous Surgery, Xijing Hospital, Air Force Medical University, No.127 Changle West Road, Xincheng District, Xi'an, 710032, Shaanxi, China.
Background: Hypertrophic scar (HS) is a severe skin fibrosis. Transplanting stem cells carrying anti-fibrotic cytokine genes, like interferon-gamma (IFN-γ), is a novel therapeutic strategy. Human amniotic epithelial cells (hAECs) are ideal seed cells and gene vectors.
View Article and Find Full Text PDFInfection-Related Stillbirths: A Detailed Examination of a Nine-Year Multidisciplinary Study.
Microorganisms
January 2025
Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Background: Although several conditions and specific risk factors have been associated with stillbirth (SB), in most of the cases it is difficult to identify the definitive etiopathology and cause of death. Specifically, the role of infections in SB is still debated. Our aim was to study maternal, placental, and fetal tissues in cases of SB in order to define the causative link between infections and fetal death, through a multidisciplinary clinical audit.
View Article and Find Full Text PDFIntrauterine and Neonatal Deaths: The 2013-2023 Experience of the Cuyahoga County Medical Examiner's Office.
Am J Forensic Med Pathol
January 2025
Deputy Medical Examiner, Cuyahoga County Medical Examiner's Office, Cleveland, OH.
Forensic investigation of intrauterine and perinatal deaths can be challenging, given their relative infrequency and the possible involvement of maternal substance use, trauma, and socioeconomic factors. Intrauterine and perinatal deaths investigated by the Cuyahoga County Medical Examiner's Officer between 2013-2023 were reviewed. One hundred twenty-eight cases were identified (83 stillborn and 45 live births).
View Article and Find Full Text PDFPredictive Model for Histological Chorioamnionitis Risk in Parturients with Intrapartum Fever.
Ther Hypothermia Temp Manag
January 2025
Department of Gynecology and Obstetrics, Fujian Provincial Maternity and Children's Hospital, Fuzhou, China.
This study aimed to analyze the causative factors of histological chorioamnionitis (HCA) in parturients with intrapartum fever, assess the implications for maternal and neonatal outcomes, and develop a predictive model to enhance clinical decision-making. A retrospective analysis was performed on 408 parturients with intrapartum fever at Fujian Provincial Maternal and Child Health Hospital from January 2022 to June 2023. Based on post-delivery placental pathology, the data were categorized into HCA (249 cases) and non-HCA groups (159 cases).
View Article and Find Full Text PDFSeroma under the amniotic membrane following simple limbal epithelial transplantation.
BMJ Case Rep
January 2025
Cornea, Dr Shroff's Charity Eye Hospital, New Delhi, India
A woman in her 50s underwent simple limbal epithelial transplantation (SLET) in the left eye for chemical injury with total limbal stem cell deficiency. A seroma, a hitherto unreported complication of the procedure was noted on the 10th postoperative day. It was associated with an accumulation of inflammatory cells and exudates in the inferior part of the amniotic membrane resembling a hypopyon.
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