Antibiotic-resistant bifidobacteria have the ability to actively interact with mucosal tissue from the intestine of mice and rats in vitro and to adapt well in the intestinal tract of normal and germ-free rats, when introduced both with and without antibiotics; in some cases antibiotics enhance the ability of bifidobacteria to adapt in the intestine. The interaction between antibiotic-resistant bifidobacteria and mucosal tissue from the intestine remains unaffected by the prolonged action of 0.1M SDS and Tween-80 solutions, 0.1% trypsin and hyaluronidase. Antibiotic-resistant bifidobacteria introduced into the intestinal tract of rats in combination with gentamycin effectively inhibit the multiplication of exogenous enterobacteria infecting the digestive tract after the cessation of the antibiotic administration.
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Microorganisms
October 2024
Unit of Microbiomics and Unit of Research of Microbiome, Bambino Gesù Children's Hospital, IRCCS, 00146 Rome, Italy.
infection (CDI) is generally treated with vancomycin, metronidazole or fidaxomicin, although fecal microbiota transplantation (FMT) represents a promising therapeutic option for antibiotic-resistant recurrent infections (rCDIs) in adults. In pediatric cystic fibrosis (CF) patients, CDIs are generally asymptomatic and respond to treatment. Here, we present the case of an 8-year-old female, initially diagnosed as "CFTR-related metabolic syndrome/cystic fibrosis screen positive, inconclusive diagnosis" (CMRS/CFSPID), who then progressed to CF at 12 months.
View Article and Find Full Text PDFAntibiotics (Basel)
September 2024
Department of Biomolecular Sciences, School of Life Sciences, Chemistry and Pharmacy, Faculty of Health, Science, Social Care and Education, Kingston University London, Kingston upon Thames KT1 2EE, UK.
The global emergence of antibiotic-resistant zooanthroponotic strains, producing extended-spectrum beta-lactamases (ESBL-E) and persisting in the intestines of farm animals, has now led to the development of a pandemic of extra-intestinal infectious diseases in humans. The search for innovative probiotic microorganisms that eliminate ESBL-E from the intestines of humans and animals is relevant. Previously, we received three isolates of bifidobacteria: from milk of a calved cow (BLLT1), feces of a newborn calf (BLLT2) and feces of a three-year-old child who received fresh milk from this calved cow (BLLT3).
View Article and Find Full Text PDFNPJ Biofilms Microbiomes
September 2024
Microbes, Infection and Microbiomes, College of Medicine and Health, University of Birmingham, Birmingham, B15 2TT, UK.
The gut microbiota of infants in low- to middle-income countries is underrepresented in microbiome research. This study explored the faecal microbiota composition and faecal cytokine profiles in a cohort of infants in a rural province of Cambodia and investigated the impact of sample storage conditions and infant environment on microbiota composition. Faecal samples collected at three time points from 32 infants were analysed for microbiota composition using 16S rRNA amplicon sequencing and concentrations of faecal cytokines.
View Article and Find Full Text PDFIran J Microbiol
August 2024
Applied Microbiology Research Center, Biomedicine Technologies Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Background And Objectives: The most common cause of healthcare-associated diarrhea is infection (CDI), which causes severe and recurring symptoms. The increase of antibiotic-resistant requires alternate treatments. Postbiotics, metabolites produced by probiotics, fight CDI owing to their antibacterial capabilities.
View Article and Find Full Text PDFGut Microbes
August 2024
APC Microbiome Ireland, University College Cork, Cork, Ireland.
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