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RNA G-quadruplex structure-based PROTACs for targeted DHX36 protein degradation and gene activity modulation in mammalian cells.
Nucleic Acids Res
January 2025
Department of Chemistry and State Key Laboratory of Marine Pollution, City University of Hong Kong, Hong Kong SAR 999077, China.
RNA G-quadruplexes (rG4s) are non-canonical secondary nucleic acid structures found in the transcriptome. They play crucial roles in gene regulation by interacting with G4-binding proteins (G4BPs) in cells. rG4-G4BP complexes have been associated with human diseases, making them important targets for drug development.
View Article and Find Full Text PDFAnti-melanogenic effects of hydroxyethyl chrysin through the inhibition of tyrosinase activity: and approaches.
Heliyon
January 2025
Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, 56212, Republic of Korea.
The suppression of tyrosinase (TYR), a key enzyme in melanogenesis, has been suggested as an effective strategy for preventing melanin accumulation. We previously discovered the novel chrysin derivative hydroxyethyl chrysin (HE-chrysin) through an irradiation technique, which exerted higher anti-inflammatory and anti-cancer activities than original chrysin. In the present study, we explored whether HE-chrysin has antioxidant and anti-melanogenic capacity using B16F10 murine melanoma cells and molecular docking.
View Article and Find Full Text PDFupregulates the immune inhibitory receptor in colorectal cancer cells via the activation of ALPK1.
Gut Microbes
December 2025
Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands.
is a Gram-negative oncobacterium that is associated with colorectal cancer. The molecular mechanisms utilized by to promote colorectal tumor development have largely focused on adhesin-mediated binding to the tumor tissue and on the pro-inflammatory capacity of . However, the exact manner in which promotes inflammation in the tumor microenvironment and subsequent tumor promotion remains underexplored.
View Article and Find Full Text PDFChloroplast State Transitions Modulate Nuclear Genome Stability via Cytokinin Signaling in Arabidopsis.
Mol Plant
January 2025
Institute of Medical Plant Physiology and Ecology, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006 People's Republic of China; State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People's Republic of China; Chinese Medicine Guangdong Laboratory, Guangdong Hengqin, People's Republic of China. Electronic address:
Activities of the chloroplasts and nucleus are coordinated by retrograde signaling, which has crucial roles in plant development and environmental adaptation. However, the connection between chloroplast status and nuclear genome stability is not well understood. Chloroplast state transitions allow the plant to balance the absorption capacity of the photosystems in an environment in which the light quality was changing.
View Article and Find Full Text PDFThe mycobacterial ABC transporter IrtAB employs a membrane-facing crevice for siderophore-mediated iron uptake.
Nat Commun
January 2025
Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
The mycobacterial ABC transporter IrtAB features an ABC exporter fold, yet it imports iron-charged siderophores called mycobactins. Here, we present extensive cryo-EM analyses and DEER measurements, revealing that IrtAB alternates between an inward-facing and an outward-occluded conformation, but does not sample an outward-facing conformation. When IrtAB is locked in its outward-occluded conformation in nanodiscs, mycobactin is bound in the middle of the lipid bilayer at a membrane-facing crevice opening at the heterodimeric interface.
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