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A Novel Spectrofluorimetric Determination of Antazoline and Xylometazoline in their Ophthalmic Formulation; Green Approach and Evaluation.
J Fluoresc
February 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Future University in Egypt, Cairo, 11835, Egypt.
A green developed spectrofluorimetric method has been applied for Antazoline (ANT) and Xylometazoline (XLO) determination in both pharmaceutical formulation and pure form. The developed method is synchronous spectrofluorimetry coupled with the second derivative mathematical tool for the determination of antazoline and xylometazoline in their dosage form. The developed method depends on reacting the cited drugs with dansyl chloride, a suitable derivatizing agent, to generate highly fluorescent derivatives.
View Article and Find Full Text PDFDevelopment of an intranasal formulation containing indomethacin and xylometazoline for rhinosinusitis treatment.
Eur Rev Med Pharmacol Sci
December 2022
Department of Otorhinolaryngology, Alaaddin Keykubat University, Alanya Training and Research Hospital, Alanya, Turkey.
Objective: Use of the nasal route of drug administration dates back many years and is used both to achieve topical treatments and to allow systemic absorption. The objective was to develop a formulation with novel features which enhance prolonged contact with the nasal and sinusal lining, since this should increase any therapeutic benefit. The anti-inflammatory drug selected was indomethacin, which was combined with xylometazoline, an effective nasal decongestant agent.
View Article and Find Full Text PDFWhat is the most appropriate hemostatic material during pediatric adenoidectomy? A prospective comparative randomized double-blinded controlled study.
Int J Pediatr Otorhinolaryngol
May 2022
Otolaryngology Department, Sapienza University of Rome, Italy.
Objectives: To evaluate the effect of different hemostatic materials used in adenoidectomy operations to improve the quality of life with the most negligible hazardous impact on pediatric health.
Study Design: a prospective, case-series, randomized, controlled, double-blinded study.
Setting: All adenoidectomy surgeries were performed between September 2016 to December 2019 at tertiary referral institutions.
A comparison of the effects of epinephrine and xylometazoline in decreasing nasal bleeding during nasotracheal intubation.
J Dent Anesth Pain Med
December 2017
Department of Anesthesiology and Pain Medicine, Dankook University College of Medicine, Cheonan, Republic of Korea.
Background: Various techniques have been introduced to decrease complications during nasotracheal intubation. A common practice is to use nasal packing with a cotton stick and 0.01% epinephrine jelly.
View Article and Find Full Text PDFSimultaneous Determination of Cromolyn Sodium Combined Dosage Forms Using Isocratic HPLC Method.
J Chromatogr Sci
January 2017
Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, 35516 Mansoura, Egypt.
A simple and selective reversed-phase high-performance liquid chromatography method was developed for the estimation of cromolyn sodium (CRM) with either oxymetazoline hydrochloride (OMZ) or xylometazoline hydrochloride (XMZ) in their binary mixtures. The method is based on the simultaneous separation of each drug in a reversed-phase Waters symmetry C18 column (250 mm × 4.6 mm intradermally, 5-µm particle size) at 25°C.
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