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Prospects of anti-GD2 immunotherapy for retinoblastoma.
Front Immunol
December 2024
Affiliated Hospital of Shandong Second Medical University,School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China.
Article Synopsis
- - Retinoblastoma is the most common eye tumor in young children, and existing treatments like chemotherapy and surgery can have serious side effects, including blindness and toxic reactions.
- - Immunotherapy, especially targeting the GD2 sphingolipid found on retinoblastoma cells, shows promise due to its lower toxicity and potential to improve patient quality of life.
- - Anti-GD2 therapies, such as the monoclonal antibody Dinutuximab, CAR-T therapy, GD2 vaccines, and nanoparticles are emerging as effective treatments, but there are still challenges to overcome in their application.
Rehabilitation report of 2 cases of spinal cord ischemic injury after intra-aortic repair.
Medicine (Baltimore)
July 2024
Mater Research, South Brisbane, QLD, Australia.
Rationale: Spinal cord ischemia injury is a serious complication after intra-aortic surgery, with a low incidence but high disability rate. However, patients often do not receive comprehensive treatment in the early stages of the disease. Therefore, active neurological intervention is needed to protect and prevent spinal cord ischemia during and after surgery.
View Article and Find Full Text PDFDepletion of b-series ganglioside prevents limb length discrepancy after growth plate injury.
BMC Musculoskelet Disord
July 2024
Department of Orthopaedic Surgery, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-Ku, Sapporo, Hokkaido, 060-8638, Japan.
Introduction: Growth plate damage in long bones often results in progressive skeletal growth imbalance and deformity, leading to significant physical problems. Gangliosides, key glycosphingolipids in cartilage, are notably abundant in articular cartilage and regulate chondrocyte homeostasis. This suggests their significant roles in regulating growth plate cartilage repair.
View Article and Find Full Text PDFPatients with stage III resectable melanoma carry a high risk of melanoma recurrence that ranges from approximately 40% to 90% at 5 years following surgical management alone. Postoperative systemic adjuvant therapy targets residual micrometastatic disease that could be the source of future recurrence and death from melanoma. Randomized phase III adjuvant trials reported significant improvements in overall survival with high-dose interferon α in 2 of 3 studies (compared with observation and GMK ganglioside vaccine) and with anti-cytotoxic T-lymphocyte antigen 4 ipilimumab at 10 mg/kg compared with placebo and ipilimumab 3 mg/kg compared with high-dose interferon α.
View Article and Find Full Text PDFPerioperative changes in ganglioside monosialodihexosylganglioside (GM3) molecular species for benign prostatic hyperplasia: a preliminary report.
Transl Androl Urol
January 2024
Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Benign prostatic hyperplasia (BPH) progresses with age and is associated with chronic inflammation. We focused on the relationship between BPH and ganglioside monosialodihexosylganglioside (GM3), a sialic acid-containing glycosphingolipid that is involved in chronic inflammation. GM3 molecular species would have a significant role in regulating inflammatory processes.
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