Albumin synthesis was studied in the isolated perfused rabbit liver under the influence of the stresses of fasting and acute alcohol and acetaldehyde exposure. Fasting clearly depressed albumin production and disaggregated the endoplasmic membrane-bound polysomes. Acute exposure to alcohol produced the same results. Acetaldehyde 2 mg% resulted in a depression of albumin synthesis but the polysomes were not disaggregated. The metabolism of alcohol was necessary for polysome disaggregation. The acute effects of ethanol and fasting were quite similar and it might be considered that the alcohol was acting like a pharmacologic fast. Employing the liver from a fasted donor specific amino acids infused into the liver at levels of 10 mM reversed the acute effects of fasting and the acute effects of exposure to ethanol. However when the two stresses of fasting and alcohol were combined the same amino acids were not effective. In studying albumin synthesis and/or secretion it is necessary to carefully define the nutritional status of the experimental model.
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