An enzyme-linked immunosorbent assay (ELISA) using a soluble antigen prepared from the D strain of Chlamydia trachomatis was used for titration of IgG antibodies to Chlamydia trachomatis in 153 sera from 126 patients with non-specific genital infection and from 27 healthy subjects. The results were compared to those obtained with the micro-immunofluorescence method and were in complete agreement in 143 of the 153 sera. The ELISA proved to be reproducible and as sensitive as the micro-immunofluorescence method.
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