AI Article Synopsis
- Hyperinsulinemic hypoglycemia in neonates is often caused by nesidioblastosis, which is linked to undeveloped pancreatic endocrine cells from fetal development.
- In adults, this condition typically arises from insulinoma or beta-cell hyperplasia, with cases of nesidioblastosis in adults being reported only recently.
- The article details the microscopic features of this disease, discusses its embryology and treatment options, and highlights the need for future research on the regulation of beta cell differentiation in the pancreas.
Article Abstract
Hyperinsulinemic hypoglycemia in neonates occurs most commonly secondary to nesidioblastosis, a persistence of fetal development of the endocrine cells of the pancreas. In adults, hyperinsulinemic hypoglycemia is usually due to insulinoma or beta-cell hyperplasia. Nesidioblastosis arising in adults has only recently been reported. An adult patient with nesidioblastosis has been described. The light and electron microscopic films of this entity are shown in detail, and the embryology and treatment are discussed. Further understanding of this newly described disease entity will require research on factors that regulate the differentiation of beta cells of the pancreas.
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| http://dx.doi.org/10.1016/0002-9610(83)90217-9 | DOI Listing |
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