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Dynamics and diversity of vaginal microbiota in bacterial vaginosis among Thai patients treated with metronidazole.
J Infect Public Health
February 2025
Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Research and Diagnostic Center for Emerging Infectious Diseases (RCEID), Khon Kaen University, Khon Kaen, Thailand.
Background: Bacterial vaginosis (BV) is a significant global public health issue due to its high recurrence rate and association with various adverse health effects. Understanding the composition and dynamics of the vaginal microbiota (VMB) is essential for better understanding of vaginal health and for developing effective strategies to improve BV management. The study aimed to determine the composition and diversity of the VMB in Thai women with BV before and after metronidazole (MTZ) treatment, and in healthy women.
View Article and Find Full Text PDFEvaluation of Metronidazole Resistance of Vaginal Swab Isolates from South African Women Treated for Bacterial Vaginosis.
Antibiotics (Basel)
December 2024
BioNTech R&D (Austria) GmbH, Helmut-Qualtinger-Gasse 2, 1030 Vienna, Austria.
: The high recurrence rate of bacterial vaginosis (BV) after antibiotic treatment is at least partially attributed to resistant bacteria. The CAPRISA 083 (CAP083) study investigated the influence of metronidazole (MTZ) treatment on the vaginal microbiome in 56 South African women diagnosed with BV. To explore the etiology of recurrent BV in this cohort, we retrospectively analyzed vaginal swabs collected in CAP083 before and after MTZ treatment.
View Article and Find Full Text PDFEffectiveness and tolerability of lactic acid vaginal gel compared to oral metronidazole in the treatment of acute symptomatic bacterial vaginosis: a multicenter, randomized-controlled, head-to-head pilot study.
BMC Womens Health
January 2025
Department of Obstetrics and Gynecology, University Clinic of Bern, Friedbuehlstrasse 19, Bern, 3010, Switzerland.
Background: Bacterial vaginosis (BV) is a prevalent vaginal condition among reproductive-age women, characterized by off-white, thin vaginal discharge with a fishy odor. It increases susceptibility to sexually transmitted diseases (STDs) and pelvic inflammatory disease (PID). BV involves a shift in vaginal microbiota, with reduced lactobacilli and increased anaerobic bacteria.
View Article and Find Full Text PDFEvaluation of the Efficacy of Medicinal Plants in Treating Bacterial Vaginosis: A Comprehensive Systematic Review of Interventional Studies.
Iran J Nurs Midwifery Res
November 2024
Faculty of Persian Medicine, Herbal and Traditional Medicines Research Center, Department of Traditional Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Background: Bacterial Vaginosis (BV) is the most prevalent cause of vaginal infection among women. This study aimed to summarize the evidence related to the effectiveness of medicinal plants as an alternative therapy for the management of BV.
Materials And Methods: PubMed, Scopus, Cochrane Library, Web of Science, and Medline PubMed were systematically searched.
Safety and efficacy of pharmacotherapies for pelvic inflammatory disease and endometriosis.
Expert Opin Drug Saf
January 2025
Unit of Obstetrics and Gynecology, Genoa, Italy.
Introduction: Endometriosis and pelvic inflammatory disease (PID) are gynecological conditions affecting women of reproductive age and causing pain symptoms. The symptoms caused by these conditions are similar; thus, the differential diagnosis may be challenging. The treatment of these conditions is very different because PID is treated with antibiotic therapy, while endometriosis is treated with hormonal therapies suppressing estrogen levels.
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