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How I Do It: Managing Cavitary Coccidioidomycosis Expert Opinions for Improving Patient Outcomes.
Chest
December 2024
Division of Infectious Diseases, Department of Medicine, Mayo Clinic Arizona, Phoenix, AZ, USA; University of Arizona, Tucson, AZ, USA.
Coccidioidomycosis (CM), caused by the dimorphic fungi Coccidioides immitis (C. immitis) and C. posadasii, is recognized as an increasing threat both nationally and worldwide.
View Article and Find Full Text PDFDisseminated histoplasmosis from western Mexico-rethinking our geographic distribution of endemic fungal species: a case report and review of literature.
J Med Case Rep
November 2024
Division of Pediatric Infectious Diseases, Memorial Care Miller Children's & Women's Hospital Long Beach, Clinical Professor of Pediatrics, University of California Irvine Department of Pediatrics, Irvine, CA, USA.
Background: Histoplasma is a fungal pathogen found in many parts of the world. In North America, its distribution is traditionally thought to be endemic to the Ohio and Mississippi River valleys. Development of histoplasmosis after Histoplasma exposure is related to degree of inoculum exposure and susceptibility, for example, immunocompromised status.
View Article and Find Full Text PDFMiliary coccidioidomycosis mimicking tuberculosis: Case report and review of literature.
Med Mycol Case Rep
December 2024
Department of Infectious Disease, Olive View Medical Center, Sylmar, CA, USA.
Miliary coccidioidomycosis is a severe manifestation of diseases caused by and that is endemic to the southwestern United States as well as Central and South America. While most cases of coccidioidomycosis present with pulmonary disease, certain risk factors increase the risk for disseminated disease. We present a case of miliary coccidioidomycosis in a 46-year-old patient with uncontrolled diabetes.
View Article and Find Full Text PDF[Differential diagnosis of coccidioidomycosis manifested by peripheral pulmonary lesion].
Khirurgiia (Mosk)
August 2024
Central TB Research Institute (CTRI), Moscow, Russia.
We present this clinical case as a demonstration of difficulties in differential diagnosis of pulmonary coccidioidomycosis. Differential diagnostics of peripheral pulmonary lesion performed using bronchoscopy with BAL and TBCB and video-assisted thoracic surgery (VATS) biopsy. Diagnostic specimens were tested using microbiological (luminescent microscopy, culture (BACTEC MGIT960 and Lowenstein-Jensen Medium), RT-PCR, cytological and morphological (hematoxylin-eosin, Ziehl-Neelsen, PAS, Grocott methenamine silver (GMS) stainings) examinations.
View Article and Find Full Text PDFSafety of TNF-α inhibitors: A real-world study based on the US FDA Adverse Event Reporting System Database.
Medicine (Baltimore)
July 2024
Clifford Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
Article Synopsis
- - This study investigates the adverse drug events (ADEs) linked to TNF-α inhibitors (TNFis) used in rheumatoid arthritis (RA) patients, pulling data from the FDA's reporting system to enhance clinical understanding.
- - Four common ADEs among TNFis are identified (pulmonary tuberculosis, infections, hypersensitivity, and herpes zoster), but each TNFi also has unique ADEs: Adalimumab has the highest with 63 unique events, while etanercept has 180 unique ADEs.
- - The research highlights the need for careful medication selection by clinicians, especially for RA patients with existing malignancies, due to the variety of common and unique ADEs linked to different TNFis.
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