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Tumour-Associated Macrophages in Oral Squamous Cell Carcinoma.
Oral Dis
January 2025
Bahrain Defence Force Royal Medical Services, Riffa, Bahrain.
Objective: Tumour-associated macrophages (TAMs) are crucial in the progression and treatment response of oral squamous cell carcinoma (OSCC). TAMs infiltrate OSCC, adopting an M2-like phenotype that promotes tumour growth, metastasis and immune suppression. The current narrative review explored the roles of TAMs in OSCC, focusing on their impact on the tumour microenvironment, invasion, metastasis, angiogenesis, immunosuppression and potential therapeutic targeting.
View Article and Find Full Text PDFBreast Morphogenesis: From Normal Development to Cancer.
Adv Exp Med Biol
January 2025
Stem Cell Research Unit, Biomedical Center, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
The human breast gland is composed of branching epithelial ducts that culminate in milk-producing units known as terminal duct lobular units (TDLUs). The epithelial compartment comprises an inner layer of luminal epithelial cells (LEP) and an outer layer of contractile myoepithelial cells (MEP). Both LEP and MEP arise from a common stem cell population.
View Article and Find Full Text PDFUSP33 Regulates DNA Damage Response and Carcinogenesis Through Deubiquitylating and Stabilising p53.
Cell Prolif
December 2024
China National Center for Bioinformation, Beijing, China.
The de-ubiquitinase USP33 has been shown to possess either tumour-promoting or inhibitory effect on human cancer cells. However, all these findings are mainly based on in vitro cell culture models, and the in vivo evidence, which is more plausible to digest the functional role of USP33 in carcinogenic process, is still lacking. Here, we demonstrate that USP33 modulates DNA damage responses including cell cycle arrest and apoptosis induction through associating with p53.
View Article and Find Full Text PDFOncogenic role of PMEPA1 and its association with immune exhaustion and TGF-β activation in HCC.
JHEP Rep
November 2024
Liver Cancer Translational Research Group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic, Universitat de Barcelona, Barcelona, Catalonia, Spain.
Article Synopsis
- TGF-β is implicated in promoting cancer development, and the study investigates a specific protein's role in hepatocellular carcinoma (HCC), finding its overexpression linked to aggressive cancer features.
- The research involved analyzing tumor data from a large number of HCC patients and using mouse models to explore molecular effects, revealing a connection between the protein’s levels and immune system suppression.
- The findings suggest that overexpressing this protein contributes to tumor growth and poor patient outcomes, highlighting its potential as a target for cancer treatment.
B-cell performance in chemotherapy: Unravelling the mystery of B-cell therapeutic potential.
Clin Transl Med
July 2024
Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Background And Main Body: The anti-tumour and tumour-promoting roles of B cells in the tumour microenvironment (TME) have gained considerable attention in recent years. As essential orchestrators of humoral immunity, B cells potentially play a crucial role in anti-tumour therapies. Chemotherapy, a mainstay in cancer treatment, influences the proliferation and function of diverse B-cell subsets and their crosstalk with the TME.
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