AI Article Synopsis
- The study investigates peripheral blood lymphocytes from cows with chronic lymphocytic leukemia (CLL) using various surface markers.
- Two methods for cell population enrichment and depletion were used, revealing that cells with different markers had similar characteristics.
- Adherent cells formed rosettes with sheep red blood cells and were mostly sIg positive, indicating a high presence of B-cells in this population.
Article Abstract
Peripheral blood lymphocytes (LL) from cows with chronic lymphocytic leukemia (CLL) have been studied using a number of surface markers. Cell populations were obtained by partial enrichment and depletion using Sephadex G-200-anti-F(ab')2 and Sephadex G-200-anti-LL-Ig immunoadsorbent columns. It was shown that cell populations having different markers, i.e., surface immunoglobulins (sIg) and leukemia-associated antigens (LAA), are characterized by similar parameters. Thus the adherent cells obtained by both fractionation methods formed 1.1-4.0% of rosettes with sheep red blood cells, while 90.6-94.3% were sIg positive cells. The cytotoxicity test (CTT) performed with anti-B and anti-LL sera indicated that a vast majority of adherent cells reacted to the sera. Thus the adherent cells represent a population with a high percentage of B-cells.
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| http://dx.doi.org/10.1016/0165-2427(84)90085-0 | DOI Listing |
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