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Impact of gestational diabetes on depression and breastfeeding self-efficacy in the postpartum period in a selected hospital of Bhubaneswar.
J Family Med Prim Care
December 2024
Department of Obstetric and Gynaecology Nursing, Kalinga Institute of Nursing Sciences, KIIT Deemed to be University, Patia, Bhubaneswar, Odisha, India.
Background: Gestational diabetes mellitus (GDM) is the most common medical complication and metabolic disorder of pregnancy. The prevalence of GDM in all pregnancies is approximately 7%. Globally, there are 14% pregnancies with significant variability in prevalence based on diagnostic criteria, sociodemographic characteristics, and geographic region.
View Article and Find Full Text PDFBreaking the energy chain: importance of ATP synthase in and its potential as a drug target.
RSC Med Chem
January 2025
Infectious Diseases Division, CSIR - Indian Institute of Integrative Medicine Jammu-180001 India
Unveiling novel pathways for drug discovery forms the foundation of a new era in the combat against tuberculosis. The discovery of a novel drug, bedaquiline, targeting mycobacterial ATP synthase highlighted the targetability of the energy metabolism pathway. The significant potency of bedaquiline against heterogeneous population of marks ATP synthase as an important complex of the electron transport chain.
View Article and Find Full Text PDFAssessment of public literacy in TB prevention and control in the National 13th Five-Year plan for Tuberculosis Prevention and Control (2016-2020) in China.
BMC Health Serv Res
January 2025
School of Public Health, Lanzhou University, Lanzhou, Gansu, China.
Background: China has always been a country with a high burden of tuberculosis. In order to end TB, the Chinese government launched three plans for TB prevention and control. The Chinese government implemented the National 13th Five-Year plan for Tuberculosis Prevention and Control (2016-2020) to promote TB prevention and control from policy, technology, health promotion and other aspects from 2016 to 2020.
View Article and Find Full Text PDFPopulation pharmacokinetics of bedaquiline: a systematic review.
Eur J Clin Pharmacol
January 2025
Department of Pharmacy, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, 310000, Zhejiang, China.
Background And Objectives: Bedaquiline (BDQ) plays a critical role in the treatment of multidrug-resistant tuberculosis (MDR-TB). However, the large pharmacokinetic (PK) variability of BDQ presents a significant challenge in its clinical use. This study aimed to summarize the population PK characteristics of BDQ and to identify significant covariates affecting the PK variation of BDQ.
View Article and Find Full Text PDFGeneXpert MTB/RIF Ultra in Pediatric Tuberculosis: How Disease Characteristics Modify Test Performances.
Curr Pediatr Rev
January 2025
Department of Health Sciences, University of Florence, Florence, Italy.
Introduction: The diagnosis of pediatric tuberculosis (TB) is challenging, due to the lower sensitivity of microbiological tests, such as culture and microscopy, compared to their performance in adult cases. Guidelines have introduced molecular tests, including GeneXpert MTB/ RIF and GeneXpert MTB/RIF Ultra. These tests use a real-time polymerase chain reaction method and provide information on M.
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