PGE2 overproduction by a nephroblastoma associated with hypercalcemia was clearly demonstrated in a 2-month-old girl. Compared with normal tissue, tumor showed greater phospholipase A2 and PGE2 synthetase activities but metabolized PGE2 at a faster rate. Of the enzymes involved in PGE2 synthesis, those which transform arachidonic acid into PGE2 seem to be more active.
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| http://dx.doi.org/10.1002/1097-0142(1984)54:4<635::aid-cncr2820540408>3.0.co;2-m | DOI Listing |
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