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Meta-assembly of genomic associations to identify cattle fat depot candidate genes and pleiotropic effects.

BMC Genomics

December 2024

School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Roseworthy, South Australia, 5371, Australia.

Background: Fat traits in cattle are considered important due to their contribution to beef eating quality and carcass economic value. Discovering the genes controlling fat traits in cattle will enable better selection of these traits, but identifying these genes in individual experiments has proven difficult. Compared to individual experiments, meta-analyses allow greater statistical power for detecting quantitative trait loci and identifying genes that influence single and multiple economically important fat traits.

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Organ function declines with age, and large-scale transcriptomic analyses have highlighted differential aging trajectories across tissues. The mechanism underlying shared and organ-selective functional changes across the lifespan, however, still remains poorly understood. Given the central role of mitochondria in powering cellular processes needed to maintain tissue health, we therefore undertook a systematic assessment of respiratory activity across 33 different tissues in young (2.

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Article Synopsis
  • Local steroid injections provide short-term pain relief for tennis elbow, but novel treatments like autologous blood injections may offer more effective results.
  • The study compared the effectiveness of steroid injections versus autologous blood injections in 396 patients suffering from lateral epicondylitis over 12 weeks.
  • Results showed that patients receiving autologous blood injections reported significantly lower pain levels than those receiving steroid injections, with a notable p-value of 0.0001 indicating strong statistical significance.
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Epicardial adipose tissue (EAT) is a unique fat depot located between the myocardium and the visceral layer of pericardium. It can be further subdivided into pericoronary (PCAT), periatrial (PAAT) and periventricular adipose tissue (PVentAT), each of them exhibiting specific characteristics and association with the underlying tissue. Since no physical barrier separates EAT from the myocardium, this fat tissue can easily interact with the underlying cardiac structure.

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Associations between visceral and liver fat and cardiac structure and function: a UK Biobank study.

J Clin Endocrinol Metab

September 2024

Department of Cardiology, The Second Affiliated Hospital, Xi'an Jiaotong University, No. 157, West 5th Road, Xi'an, 710004, Shaanxi, China.

Context: Different fat depots have connected to cardiovascular health.

Objective: We assessed the associations of abdominal magnetic resonance-quantified visceral adipose tissue (VAT) and liver fat (proton density fat fraction, PDFF) with cardiac magnetic resonance (CMR)-measured cardiac structure and function, and considered potential mechanism.

Methods: Our study encompassed 10,920 participants from the UK Biobank.

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