A 35-year-old homosexual man with acquired immune deficiency syndrome developed progressive dementia and spastic quadriparesis over a two-month period. Severe symmetrical, bilateral degeneration of the corticospinal and frontopontine fibers and cerebellar white matter were found postmortem. Several glial nodules in the brainstem and cerebellum suggested "smoldering" brainstem encephalitis. The possible association of the adenovirus that was isolated from the patient's cerebrospinal fluid to these obscure changes in the central nervous system is discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ana.410150518 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Long-term sublingual bacterial immunotherapy prevents ear, nose and throat infections: A real-life study.
SAGE Open Med
January 2025
Allergy and Immunology Service Hospitale Maternidade Therezinha de Jesus, Juiz de Fora, Brazil.
Objective: Bacterial extracts have been used for many years to prevent airway infections. Recent findings suggest that immunity can be trained by inducing an immunological memory in both the innate and acquired immune response. This real-life observational study investigated the potential of sublingual bacterial immunotherapy in the prevention of ear, nose, and throat infections.
View Article and Find Full Text PDFThe independent predictive value of admission serum ferritin concentration for prognosis in elderly patients with community-acquired pneumonia in the emergency department.
Front Cell Infect Microbiol
January 2025
Emergency Medicine Clinical Research Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Background: Community-acquired pneumonia (CAP) poses a significant health threat to the elderly population, leading to high morbidity and mortality rates. Serum ferritin, a critical indicator of iron metabolism, plays a pivotal role in inflammation and immune regulation. Nevertheless, its specific prognostic relevance in elderly patients with CAP remains unclear.
View Article and Find Full Text PDFA case of relapsed gAChR-positive autoimmune autonomic ganglionopathy treated by plasma exchange and mycophenolate mofetil.
Front Neurol
January 2025
Department of Neurology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.
Autoimmune autonomic ganglionopathy (AAG) is a rare and acquired immune-mediated disease that leads to wide autonomic failure, mainly characterized by orthostatic hypotension, gastrointestinal dysfunction, anhidrosis and poorly reactive pupils. This disorder is usually associated with autoantibodies to the ganglionic nicotinic acetylcholine receptor (gAChR-Ab). In this study, we describe a case of a gAChR-Ab-positive AAG patient with two therapeutic stages.
View Article and Find Full Text PDFSynergizing Digital and Physical Approaches: Experience Summary of the HIV PrEP Promotion Project.
China CDC Wkly
January 2025
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
China's human immunodeficiency virus / acquired immune deficiency syndrome (HIV/AIDS) prevention and control efforts have entered a new stage, necessitating the exploration of more effective intervention strategies. HIV pre-exposure prophylaxis (PrEP) is a proven method to prevent HIV infection, but its promotion in China faces challenges such as low public acceptance and inadequate service capacity. To further promote PrEP, the "HIV PrEP Model Exploration Project" was launched, exploring three PrEP service models: PrEP clinics, Digital services and physical testing, and PrEP self-service vending machines.
View Article and Find Full Text PDFDendritic cells in developing and adult zebrafish arise from different origins and display distinct flt3 dependencies.
Development
January 2025
Department of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Dendritic cells (DCs) are key cellular components of the immune system and perform critical functions in innate and acquired immunity. In mammals, it is generally believed that DCs originate exclusively from hematopoietic stem cells (HSCs). Using a temporal-spatial resolved fate-mapping system, here we show that in zebrafish, DCs arise from two sources: dorsal aorta-born endothelium-derived hematopoietic progenitors (EHPs) and HSCs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!