Two cases of mycobacterial histiocytosis in infants with the morphological signs of a combined immune defect are reported. In the first case the seven months aged male infant died of a generalized BCG infection. In the second case the mycobacterial histiocytosis of mesenterial lymph nodes was an incidental finding of autopsy in a female infant four month of age, whose cause of death was a generalized cytomegaly. The morphological picture and the histological differential diagnosis of mycobacterial histiocytosis are discussed.

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