The ftsZ ( sulB ) coding sequence is preceded by two promoters, at least one of which lies within the coding sequence of the neighboring gene, ftsA . This region of the ftsA gene is required for full biological activity of ftsZ .
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| http://dx.doi.org/10.1128/jb.158.3.1198-1201.1984 | DOI Listing |
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Article Synopsis
- Researchers have identified genetic polymorphisms of ABI3 as a risk factor for late-onset Alzheimer's Disease (LOAD), but the role of ABI3 in microglia is not well understood.
- Using CRISPR/Cas9, a specific risk variant (S212F) was introduced into mouse models to study its effects on AD-related pathologies alongside 5xFAD mice over time.
- Results showed that the 5xFAD/Abi3 mice exhibited a decrease in amyloid beta plaque burden and a significant reduction in microglia numbers with age, suggesting ABI3 may influence both plaque formation and microglial response in AD pathology.
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