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Atmospheric endocrine disruptors: A systematic review on oestrogenic and androgenic activity of particulate matter.
Chemosphere
February 2024
Department of Public Health and Pediatrics, University of Torino, Torino, 10126, Italy. Electronic address:
The alarming human health effects induced by endocrine disruptors (ED) have raised the attention of public opinion and policy makers leading worldwide to regulations that are continuously improved to reduce exposure to them. However, decreasing the exposure levels is challenging because EDs are ubiquitous and exposure occurs through multiple routes. The main exposure route is considered ingestion, but, recently, the inhalation has been hypothesized as an important additional route.
View Article and Find Full Text PDFBlocking of oestrogen signals improves anti-tumour effect regardless of oestrogen receptor alpha expression in cancer cells.
Br J Cancer
October 2023
Division of Immunobiology, Graduate School of Medicine, Institute for Genetic Medicine, Hokkaido University, Kita-15 Nishi-7, Sapporo, 060-0815, Japan.
Background: Anti-oestrogenic therapy has been used for breast cancer patients with oestrogen susceptibility cancer cells. However, little has been known about its potential role for immune cell biology within TME, particularly in cancer patients without oestrogen sensitivity of tumour cells. Therefore, we aimed to study the effect of oestrogen on immunity within TME.
View Article and Find Full Text PDFElacestrant demonstrates strong anti-estrogenic activity in PDX models of estrogen-receptor positive endocrine-resistant and fulvestrant-resistant breast cancer.
NPJ Breast Cancer
November 2022
Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, SW7 3RP, UK.
Article Synopsis
- Fulvestrant, a selective estrogen receptor degrader (SERD), is limited in breast cancer treatment due to low oral bioavailability, while the investigational SERD elacestrant is more effective and can be taken orally.
- Both drugs are shown to negatively affect tumor growth in ER+ patient-derived models, but elacestrant remains effective even after resistance develops against fulvestrant.
- When used in conjunction with CDK4/6 inhibitors, elacestrant enhances anti-cancer effects and demonstrates potential against drug-resistant cells, signifying the need for further clinical testing.
Mitigating the Adverse Effects of Polychlorinated Biphenyl Derivatives on Estrogenic Activity via Molecular Modification Techniques.
Int J Environ Res Public Health
May 2021
MOE Key Laboratory of Resources Environmental Systems Optimization, College of Environmental Science and Engineering, North China Electric Power University, Beijing 102206, China.
The aim of this paper is to explore the mechanism of the change in oestrogenic activity of PCBs molecules before and after modification by designing new PCBs derivatives in combination with molecular docking techniques through the constructed model of oestrogenic activity of PCBs molecules. We found that the weakened hydrophobic interaction between the hydrophobic amino acid residues and hydrophobic substituents at the binding site of PCB derivatives and human oestrogen receptor alpha (hERα) was the main reason for the weakened binding force and reduced anti-oestrogenic activity. It was consistent with the information that the hydrophobic field displayed by the 3D contour maps in the constructed oestrogen activity CoMSIA model was one of the main influencing force fields.
View Article and Find Full Text PDFstudies on inhibition capability of fungal-sourced bassiatin versus tamoxifen against ERα, EGFR and VEGFR on breast cancer cells.
Mycoscience
March 2021
b Hacettepe University, Department of Biology.
Bassiatin which is produced by some fungi, is morpholine-based depsipeptide. Recent studies show that bassiatin inhibits MCF-7 breast cancer cell proliferation with its anti-oestrogenic effect. In this study, bassiatin's inhibition versus Tamoxifen was examined by comparing the effects on epidermal growth factor receptor and vascular endothelial growth factor receptor in addition to oestrogen receptor on breast cells.
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