AI Article Synopsis
- The study investigated Bovine papillomavirus type 1 (BPV-1) fibrosarcomas in Syrian hamsters using G- and C-banding techniques to analyze chromosomal changes.
- All tumor-derived cells exhibited stable chromosomal abnormalities during multiple transplantations, while some cells without such abnormalities were linked to the host animal's genetic variations.
- The tumors mostly contained pseudodiploid cells, with some being hypodiploid and others displaying hyperdiploid clones, particularly showing frequent aberrations involving chromosomes #1, #4, and #15.
Article Abstract
Bovine papillomavirus type 1 (BPV-1) induced fibrosarcomas in the Syrian hamster were studied cytogenetically by G- and C-banding techniques. All tumor derived cells showed chromosome abnormalities that remained stable during serial tumor transplantations. Cells without chromosome abnormalities found in two cultures were derived from the host animals on account of heterochromatin polymorphisms. In most tumors pseudodiploid cells prevailed, some cells were hypodiploid lacking one or two chromosomes, and one tumor showed two hyperdiploid cell clones with one and three additional chromosomes, respectively. Some of the chromosome abnormalities apparently are nonrandom. Three chromosomes (#1, #4, and #15) were most frequently involved in aberrations.
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| http://dx.doi.org/10.1016/0165-4608(84)90127-4 | DOI Listing |
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