A case of true cutaneous histiocytosarcoma --or Crosti's reticulosis--is reported, and provides the basis for a discussion of the techniques at present used in defining the histiocytic origin of lymphomas, criteria for assessing the malignancy of histiocytic infiltrates, and clinical data and course of histiocytic sarcomas. Particular emphasis is laid on the characteristics of Crosti's reticulosis, which the authors consider to be a form of histiocytic sarcoma, usually with a favorable outcome. They also attempt to isolate pathological criteria for assessing the prognosis of the disease, which appears to vary substantially from case to case. Setting aside cases which had not been studied by both ultrastructural and enzymo-immunological techniques, the authors found only the twenty-two cases of primary cutaneous histiocytosarcoma in dermatological literature, including their own.
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A case of true cutaneous histiocytosarcoma --or Crosti's reticulosis--is reported, and provides the basis for a discussion of the techniques at present used in defining the histiocytic origin of lymphomas, criteria for assessing the malignancy of histiocytic infiltrates, and clinical data and course of histiocytic sarcomas. Particular emphasis is laid on the characteristics of Crosti's reticulosis, which the authors consider to be a form of histiocytic sarcoma, usually with a favorable outcome. They also attempt to isolate pathological criteria for assessing the prognosis of the disease, which appears to vary substantially from case to case.
View Article and Find Full Text PDFReporting a case of cutaneous tumor of the back of recent occurrence and rapid increase in a 79-years-old woman, according to Crosti's "reticulosis", the authors discuss the following points:--the histiocytic nature of the tumor cells particularly based on immunohistochemical studies (peroxidase activity, anti-HTLA serum) and on electron microscopy with special reference to the multivesicular bodies found in their cytoplasm;--the tests for correct identification of the histiocyte (including electron microscopy, tests for HTLA and HBLA antigens, peroxidatic reaction, acid phosphatase activity, and in vivo or in vitro phagocytosis);--the out of date character of the concept of malignant "reticulosis" in the hematologica and dermatologic classifications, the recent advances in the knowledge of the nature of the so-called "reticulum" (or "reticular") cell which seems to be a distinct entity derived from the mesenchymal cell (as the fibroblast);--the clinical and evolutive characteristics of histiocytic tumors (no hematologic involvement, slow evolution, high radiosensitivity), the difficulties in defining their malignancy and, above all, in finding comparable references in the literature with complete cellular study;--the nosologic place of this affection among the group of haematodermas and in the pathology of the mononuclear phagocyte system. The generic term of cutaneous histiocytosarcoma (stage I or II) is suggested, including the whole malignant and isolated tumoral proliferations developing from the dermic histiocyte.
View Article and Find Full Text PDFThe authors present a case of muco-cutaneous leishmaniasis in the Republic of Chad. In that case, a long duration treatment with corticoids entailed the generalization of the disease in the form of a secondary kala-azar and the appearance of a histiocytosarcoma on the scar left by the oriental sore. Comments on the pathogenesis of leishmaniasis are then exposed.
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