AI Article Synopsis
- The study explores how respiratory chain inhibitors and ATP-synthetase blockers affect calcium (Ca2+) and potassium (K+) transport in mitochondria when the medium is acidified with phosphate or arsenate.
- Evidence suggests that K+ and Ca2+ movements are linked to hydrogen ion (H+) leakage through the ATPase proton channel under these conditions.
- It also highlights that cation transport at low pH may involve processes like lipid peroxidation and hydrolysis, suggesting a regulatory mechanism for ion transport that connects oxidative phosphorylation with lipid changes.
Article Abstract
The effects of the respiratory chain inhibitors as well as those of the inhibitors and substrates of ATP-synthetase in Ca2+ and K+ transport induced in the mitochondria upon the medium acidification in the presence of phosphate or arsenate, were investigated. Evidence has been obtained suggesting that under the experimental conditions used the transmembrane fluxes of K+ and Ca2+ are paralleled with H+ leakage through the proton channel of ATPase. It was found also that the system inducing cation fluxes at low pH values included peroxidation and hydrolysis of phospholipids. A scheme of regulation of ion transport in the mitochondria involving oxidative phosphorylation and oxidation and hydrolysis of lipids is proposed.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Solar-Driven Nanofluidic Ion Regulation for Fractional Salt Crystallization and Reutilization.
ACS Nano
January 2025
Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Solar water evaporation (SWE) has emerged as an appealing method for water and salt recovery from hypersaline wastewater. However, different ions usually transfer and accumulate uncontrollably during ion-water separation, making salt fractionalization impractical for conventional SWE, and the resulting mixed salts are hard to use and still require significant costs for disposal. To achieve salt fractionalization and reutilization, achieving ion-water and ion-ion separation simultaneously are crucial in advancing SWE toward sustainability.
View Article and Find Full Text PDFUltrafast Lithium-Ion Transport Engineered by Nanoconfinement Effect.
Adv Mater
January 2025
School of Materials Science and Engineering, Beihang University, Beijing, 100191, China.
Amid the burgeoning demand for electrochemical energy storage and neuromorphic computing, fast ion transport behavior has attracted widespread attention at both fundamental and practical levels. Here, based on the nanoconfined channel of graphene oxide laminar membranes (GOLMs), the lithium ionic conductivity typically exceeding 10 mS cm is realized, one to three orders of magnitude higher than traditional liquid or solid lithium-ion electrolyte. Specifically, the nanoconfined lithium hexafluorophosphate (LiPF)-ethylene carbonate (EC)/ dimethyl carbonate (DMC) electrolyte demonstrates the ionic conductivity of 170 mS cm, outperforming the bulk counterpart by ≈16 fold.
View Article and Find Full Text PDFLinear Enhanced 3D Nanofluid Force-Electric Conversion Device.
Adv Mater
January 2025
Hubei key laboratory of energy storage and power battery, School of Mathematics, Physics and Optoelectronic Engineering, Hubei University of Automotive Technology, Shiyan, 442002, P. R. China.
The inherent trade-off between permeability and selectivity has constrained further improvement of passive linear force-electric conversion performance in nanofluidic pressure sensors. To overcome this limitation, a 3D nanofluidic membrane with high mechanical strength utilizing aramid nanofibers/carbon nanofiber (ANF/CNF) dual crosslinking is developed. Due to the abundant surface functional groups of CNF and the high mechanical strength of ANF, this large-scale integrated 3D nanofluidic membrane exhibits advantages of high flux, high porosity, and short ion transport path, demonstrating superior force-electric response compared to conventional 1D and 2D configurations.
View Article and Find Full Text PDFWater-in-bisalt electrolytes with mixed hydrophilic and hydrophobic anions for enhanced transport and stability for potassium-ion batteries.
RSC Adv
January 2025
Department of Chemical and Biomolecular Engineering, Case Western Reserve University Cleveland OH USA
Water-in-salt electrolytes provide an expanded electrochemical potential window, thus enabling a wide range of battery chemistries based on readily available salts and water. This study introduces a binary salt approach for achieving high K concentration with a tunable solvation sphere composed of acetate (Ac) and trifluoromethane sulfonate (OTf) anions, and water. Combining the hydrophilic low-cost potassium acetate with hydrophobic potassium trifluoromethane sulfonate salts, 36 molal liquid electrolyte, K(Ac)(OTf)·1.
View Article and Find Full Text PDFThe Effect of Magnesium Concentration on Myogenic Cardiac Function: Larval .
MicroPubl Biol
December 2024
Biology, University of Kentucky, Lexington, Kentucky, United States.
The heart of larval serves as a model preparation in addressing cardiac function, as known genetic mutations can be mimicked to examine therapies. Pharmacological agents and function of proteins, like TRPA1, which affect ionic transport and ion concentrations can be investigated for their action on cardiac function in this model. To maintain function, the larval heart tube needs to remain viable; thus, a physiological saline is required.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!