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Analysis of dissolved organic matter characteristics in pharmaceutical wastewater via spectroscopy combined with Fourier-transform ion cyclotron resonance mass spectrometry.
J Hazard Mater
November 2024
College of Environmental Science and Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, Hebei, China; Hebei Key Laboratory of Pollution Prevention Biotechnology, Shijiazhuang 050018, Hebei, China. Electronic address:
Studying the changes in organic matter and characteristic pollutants during the treatment of penicillin-containing pharmaceutical wastewater, which can be reflected by changes in dissolved organic matter (DOM), is crucial for improving the effectiveness of wastewater treatment units and systems. Herein, water quality indicators, spectroscopic methods, and Fourier-transform ion cyclotron resonance mass spectrometry were utilized to characterize the general molecular compositions and specific molecular changes in DOM during the treatment of typical penicillin-containing pharmaceutical wastewater, including in each of the influent, physicochemical treatment, biological treatment, oxidation treatment, and effluent stages. The influent exhibited a high organic matter content (concentration of dissolved organic carbon >10,000 mg·L), its DOM mainly contained protein- and lignin-like substances composed of CHON and CHONS molecules, and the relative intensity (RI) of penicillin was extremely high (RI = 0.
View Article and Find Full Text PDFProcess Development for 6-Aminopenicillanic Acid Production Using Lentikats-Encapsulated Cells Expressing Penicillin V Acylase.
ACS Omega
November 2020
Biochemical Sciences Division, National Chemical Laboratory-CSIR, Pune 411008, India.
Penicillin V acylase (PVA, EC 3.5.1.
View Article and Find Full Text PDFOptimization of aqueous two-phase systems for the production of 6-aminopenicillanic acid in integrated microfluidic reactors-separators.
N Biotechnol
December 2018
University of Chemistry and Technology, Prague, Department of Chemical Engineering, Technická 5, 166 28 Praha 6, Czech Republic. Electronic address:
Aqueous two-phase systems (ATPSs) were screened for the production of 6-aminopenicillanic acid (6-APA) catalyzed by penicillin acylase, followed by the extractive separation of 6-APA from the reaction mixture. The key point of this study was to find an ATPS exhibiting a large difference in the partition coefficients of the biocatalyst and reaction products. Several ATPSs based on polyethylene glycol (PEG)/phosphate, PEG/citrate, and PEG/dextran were tested.
View Article and Find Full Text PDFEfficient cascade synthesis of ampicillin from penicillin G potassium salt using wild and mutant penicillin G acylase from Alcaligenes faecalis.
J Biotechnol
February 2016
State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, PR China. Electronic address:
To avoid isolation and purification of the intermediate 6-aminopenicillanic acid (6-APA), a two-enzyme two-step cascade synthesis of ampicillin from penicillin G was established. In purely aqueous medium, penicillin G hydrolysis and ampicillin synthesis were catalyzed by immobilized wild-type and mutagenized penicillin G acylases from Alcaligenes faecalis (Af PGA), respectively (Fig. 1).
View Article and Find Full Text PDFUse of enzymes in the production of semi-synthetic penicillins and cephalosporins: drawbacks and perspectives.
Curr Med Chem
February 2011
Quatro G Pesquisa e Desenvolvimento LTDA., Av. Ipiranga, 6681, Tecnopuc, Predio 92A, Partenon, ZC 90619900, Porto Alegre, RS, Brazil.
Semi-synthetic β-lactamic antibiotics are the most used anti-bacteria agents, produced in hundreds tons/year scale. It may be assumed that this situation will even increase during the next years, with new β-lactamic antibiotics under development. They are usually produced by the hydrolysis of natural antibiotics (penicillin G or cephalosporin C) and the further amidation of natural or modified antibiotic nuclei with different carboxylic acyl donor chains.
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