In contrast to the mature brain, Arrhenius plots of mitochondrial cytochrome c oxidase from newborn and old rat brain show no breaks (transition temperature); the apparent activation energy of the enzyme, in the physiological range of temperature, is also significantly higher. The results indicate deficient lipid-protein interaction as well as differential fluidity status in the inner mitochondrial membranes of the newborn and aged brain. These changes may contribute to the known deficiency in oxygen consumption of the newborn and old brain.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0165-3806(84)90181-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation.
Cell Mol Life Sci
July 2024
Unidad de Biomedicina (Unidad Asociada al CSIC), Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Article Synopsis
- Lung type 2 pneumocytes (T2Ps) and alveolar macrophages (AMs) are important for making and recycling a special fluid called surfactant that helps our lungs work properly.
- The liver X receptors (LXRs), which are like switches for controlling fats and fighting inflammation, are crucial for lung health, and when they're not working, it causes problems like lung swelling and inflammation.
- Studies on mice without LXRs showed that their lungs couldn't handle surfactant properly, leading to more severe asthma symptoms, and using LXR "helping" drugs showed promise for treating lung issues.
Downregulation of the silent potassium channel Kv8.1 increases motor neuron vulnerability in amyotrophic lateral sclerosis.
Brain Commun
June 2024
F.M. Kirby Neurobiology Research Center, Boston Children's Hospital, Boston, MA 02115, USA.
While voltage-gated potassium channels have critical roles in controlling neuronal excitability, they also have non-ion-conducting functions. Kv8.1, encoded by the KCNV1 gene, is a 'silent' ion channel subunit whose biological role is complex since Kv8.
View Article and Find Full Text PDF3D-MPEA: A Graph Attention Model-Guided Computational Approach for Annotating Unknown Metabolites in Interactomics via Mass Spectrometry-Focused Multilayer Molecular Networking.
Anal Chem
May 2024
School of Food Science and Engineering, Shaanxi University of Science & Technology, Xi'an710021, China.
The spectral matching strategy of MS2 fragment spectrograms serves as a ubiquitous method for compound characterization within the matrix. Nevertheless, challenges arise due to the deficiency of distinctions in spectra across instruments caused by coelution peak-derived fragments and incompleteness of the current spectral reference database, leading to dilemma of multidimensional omics annotation. The graph attention model embedded with long short-term memory was proposed as an optimized approach involving integrating similar MS2 spectra into molecular networks according to the isotopic ion peak cluster spacing features to collapse diverse ion species and expand the spectral reference library, which efficiently evaluated the substance capture capacity to 123.
View Article and Find Full Text PDFMembrane Interaction Characteristics of the RTX Toxins and the Cholesterol-Dependence of Their Cytolytic/Cytotoxic Activity.
Int J Mol Sci
March 2024
Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country UPV/EHU, 48080 Bilbao, Spain.
RTX toxins are important virulence factors produced by a wide range of Gram-negative bacteria. They are secreted as water-soluble proteins that are able to bind to the host cell membrane and insert hydrophobic segments into the lipid bilayer that ultimately contribute to the formation of transmembrane pores. Ion diffusion through these pores leads then to cytotoxic and cytolytic effects on the hosts.
View Article and Find Full Text PDFLipid phosphorylation by a diacylglycerol kinase suppresses ABA biosynthesis to regulate plant stress responses.
Mol Plant
February 2024
Department of Biology, University of Missouri-St. Louis, St. Louis, MO 63121, USA; Donald Danforth Plant Science Center, St. Louis, MO 63132, USA. Electronic address:
Lipid phosphorylation by diacylglycerol kinase (DGK) that produces phosphatidic acid (PA) plays important roles in various biological processes, including stress responses, but the underlying mechanisms remain elusive. Here, we show that DGK5 and its lipid product PA suppress ABA biosynthesis by interacting with ABA-DEFICIENT 2 (ABA2), a key ABA biosynthesis enzyme, to negatively modulate plant response to abiotic stress tested in Arabidopsis thaliana. Loss of DGK5 function rendered plants less damaged, whereas overexpression (OE) of DGK5 enhanced plant damage to water and salt stress.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!