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Structure-function in smokers: when a small airways test really reflects the small airways.
J Appl Physiol (1985)
August 2024
Chest Department, University Hospital Erasme, Université Libre de Bruxelles (ULB), Brussels, Belgium.
If multiple-breath washout (MBW)-derived acinar ventilation heterogeneity (Sacin) really represents peripheral units, the N phase-III of the first MBW exhalation should be curvilinear. This is essentially due to the superposed effect of gas diffusion and convection resulting in an equilibration of N concentrations between neighboring lung units throughout exhalation. We investigated this in smokers with computed tomography (CT)-proven functional small airway disease.
View Article and Find Full Text PDFAntimüllerian hormone levels are associated with time to pregnancy in a cohort study of 3,150 women.
Fertil Steril
December 2024
Modern Fertility, San Francisco, California.
Objective: To study the association between antimüllerian hormone (AMH) levels and time of pregnancy. Although it has been hypothesized that serum AMH levels may indicate the chance of conception, findings have been mixed. Given that any association is expected to be modest, and it is possible that previous studies have been underpowered, we investigated this relationship in the largest prospective cohort to date.
View Article and Find Full Text PDFGenetic and early life factors influence on time-to-multiple sclerosis diagnosis: A UK Biobank study.
Mult Scler
July 2024
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Background: Previous investigations into multiple sclerosis (MS) risk factors predominantly relied on retrospective studies, which do not consider different follow-up times and assume a constant risk effect throughout lifetime.
Objective: We aimed to evaluate the impact of genetic and early life factors on MS diagnosis by employing a time-to-event analysis in a prospective cohort.
Methods: We used the UK Biobank data, considering the observation period from birth up to 31 December 2022.
A Systematic Review of the Effects of Smoking on the Cardiovascular System and General Health.
Cureus
April 2023
Community Medicine, Jagadguru Jayadeva Murugarajendra (JJM) Medical College, Davangere, IND.
The main risk factor for atherosclerotic cardiovascular disease is smoking. Nicotine and carbon monoxide are two dangerous substances that are found in cigarette smoke. The increased heart rate can have an almost instantaneous impact on the heart and blood vessels.
View Article and Find Full Text PDFCardiac Autonomic Impacts of Bushfire Smoke-A Prospective Panel Study.
Heart Lung Circ
January 2023
Menzies Institute for Medical Research, University of Tasmania, Hobart, Tas, Australia; Sydney Medical School Nepean, Faculty of Medicine and Health, Charles Perkins Centre Nepean, The University of Sydney, Sydney, NSW, Australia; Nepean Hospital, Sydney, NSW, Australia. Electronic address:
Background: Air pollution is associated with cardiovascular disease and mortality. Most studies have focussed on urban or traffic-related pollution, and less is known about the impacts from bushfire smoke on cardiovascular autonomic function, although it is associated with increased sudden cardiac death and mortality. We sought to investigate its instantaneous and short-term impacts on heart rate variability (HRV).
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