The genetic predetermination of the level of immune reactions to the injection of corpuscular pertussis vaccine and purified soluble pertussis vaccine has been revealed. Genetic differences in the intensity of immune response are manifest in both humoral and cell-mediated immunity. C57BL/6 mice belong to strains with high responsiveness, while NIHHSFS/H and CBWA mice belong to strains with low responsiveness to Bordetella pertussis.
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