Evidence for the stabilizing effect of ketoprofen on the lysosomal membrane is presented. Ketoprofen was as potent as indomethacin in stabilizing lysosomes subjected to changes in osmotic pressure. This effect was more marked in rats with adjuvant arthritis than in normal animals.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Negative effects of ketoprofen and meloxicam on distal cauda epidydimal duct contractions, testosterone levels, and sperm count in rats.
Reprod Biol
December 2024
Mode of Drug Action Laboratory, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil; Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal, Rio Grande do Norte, Brazil. Electronic address:
Article Synopsis
- The study explores the effects of ketoprofen and meloxicam, two common NSAIDs, on male reproductive health, focusing on epididymal duct contractions and sperm quality in rats.
- In vitro tests showed that meloxicam significantly reduced the contractions induced by noradrenaline, while both drugs negatively impacted testosterone levels and sperm production in vivo.
- Ketoprofen and meloxicam altered sperm parameters, with meloxicam delaying sperm transit in the epididymis, indicating potential reproductive issues linked to these medications.
Evaluation of the impact of the polymer end groups and molecular weight on in vitro and in vivo performances of PLGA based in situ forming implants for ketoprofen.
J Pharm Sci
January 2025
Advanced Drug Delivery, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, USA.
In situ forming implants are appealing long-acting dosage forms for both preclinical and clinical applications due to their simple manufacturing process and easy delivery. This study aims to develop extended-release in situ forming solid implants for subcutaneous administration using two types of commercially available triblock poly (lactic-co-glycolic acid)-poly (ethylene glycol)-poly (lactic-co-glycolic acid) (PLGA-PEG-PLGA) polymers, with either an acid or ester end group. Both types of polymers instantly form in situ implants when injected directly into an aqueous medium.
View Article and Find Full Text PDFSurfactant-Assisted Wet Granulation-Based Matrix Tablets without Exceptional Additives: Prolonging Systemic Exposure of Model BCS Class II Ketoprofen.
AAPS PharmSciTech
October 2024
Punjab University College of Pharmacy, University of the Punjab, Lahore, 54000, Pakistan.
The present study was aimed to ameliorate the issue of solubility and thereby, bioavailability of ketoprofen, a BCS Class II drug. The sustained release matrix tablets (MT) were prepared using surfactant-assisted wet granulation (SAWG) with 1-5% of different surfactants. The tablet characteristics were within the compendial limits.
View Article and Find Full Text PDFA Patent-Pending Ointment Containing Extracts of Five Different Plants Showed Antinociceptive and Anti-Inflammatory Mechanisms in Preclinical Studies.
Pharmaceutics
September 2024
Departamento de Farmacia, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Guanajuato 36200, Mexico.
: The antinociceptive and anti-inflammatory effects of a patent-pending ointment containing plant extracts from , , , , and were evaluated. : Plant extracts were chemically characterized by gas chromatography-mass spectroscopy. The antinociceptive activity of the ointment was assessed using the hot plate, tail flick, and formalin tests, whereas the anti-inflammatory activity was measured using the acute and chronic TPA-induced ear edema tests.
View Article and Find Full Text PDFMolecular insights into antimicrobial resistant Staphylococcus aureus strains: A potential zoonosis of goat origin.
Microb Pathog
November 2024
Institute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
Antimicrobial-resistant (AMR) Staphylococcus aureus (S. aureus) strains have attained global attention due to their life-threatening zoonotic nature. Being a member of ESKAPE group, S.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!