Pentagastrin as well as transmitters of its effect histamine and cAMP, affecting the HCl secretion, increased the gastric mucus secretion apparently due to stimulation of HCl production. This assumption is supported by experiments in which the histamine effect was not inhibited by cycloheximide but was completely eliminated in presence of burimamide--a drug blocking histamine H2-receptors. Prostaglandin E2 which inhibited distinctly basal secretion of HCl but did not affect the pepsin secretion, elevated markedly the mucus production. The effect of this stimulator of mucus production, which differed from histamine in its ability to inhibit HCl secretion, was mediated via the processes of translation but not of transcription. Regulation of mucus secretion in stomach, similarly to HCl and pepsin secretion, appears to involve a multicomponent cascade system, including prostaglandin E2 as one of transmitters. cascade system, including prostaglandin E2 as one of the transmitters.
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