AI Article Synopsis
- The study involved examining liver specimens from 103 patients with different liver diseases and 297 routine biopsies using orcein staining after potassium permanganate oxidation.
- Orcein-positive dark brown cytoplasmic material was found in 27 cases specifically linked to long-standing cholestasis related to conditions like primary biliary cirrhosis and certain types of hepatitis.
- The orcein-positive material was absent in congenital bilirubin metabolism disorders, hemochromatosis, and various forms of hepatitis, highlighting its specific association with chronic cholestasis.
Article Abstract
Liver specimens from 103 patients with various hepatic diseases and from 297 consecutive liver biopsies examined routinely were stained with orcein after oxidation of the tissue sections with potassium permanganate. Orcein-positive dark brown cytoplasmic material could be demonstrated in 27 cases with long-standing cholestasis. These patients had either primary biliary cirrhosis, the cholestatic liver disease of ulcerative colitis or chronic active hepatitis, advanced alcoholic cirrhosis or secondary biliary cirrhosis due to extrahepatic biliary obstruction. Orcein-positive material could not be demonstrated in congenital disorders of bilirubin metabolism or in hemochromatosis. Similarly, it could not be found in acute, toxic, alcoholic or chronic persistent hepatitis.
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