Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/jac/12.suppl_b.195 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Varicella zoster virus central nervous system infection - a retrospective study from a tertiary center in Greece.
Germs
September 2024
MD, PhD, School of Medicine, University of Crete, 71003 Heraklion, Greece.
Introduction: Central nervous system (CNS) infection due to the varicella zoster virus (VZV) can complicate the primary infection or the reactivation, leading to significant mortality and morbidity. This study aimed to describe the clinical, laboratory, and radiological characteristics of patients with confirmed VZV CNS infection in a tertiary hospital in Greece.
Methods: Data about patients hospitalized from January 2018 to September 2023 with CNS infection by VZV, confirmed by a syndromic polymerase chain reaction in the cerebrospinal fluid (CSF), were retrospectively collected and evaluated.
Optimization of antiviral dosing in Herpesviridae encephalitis: a promising approach to improve outcome?
Clin Microbiol Infect
December 2024
Institute of Medical Microbiology and Virology, University Medical Center, Göttingen, Germany.
Background: Despite established antiviral therapy for herpes simplex virus, varicella zoster and cytomegalovirus encephalitis, the outcome remains poor.
Objectives: To assess pharmacokinetic (PK) and pharmacodynamic (PD) data of antiviral drugs in the central nervous system (CNS) to optimize the treatment of Herpesviridae encephalitis.
Sources: PUBMED search 1950 to September 2024, terms (1) "encephalitis" and ("HSV" or "VZV" or "CMV") or (2) cerebrospinal and ("(val)acyclovir" or "(val)ganciclovir" or "foscarnet" or "cidofovir").
Predicting Nephrotoxic Acute Kidney Injury in Hospitalized Adults: A Machine Learning Algorithm.
Kidney Med
December 2024
Division of Pediatric Nephrology, Dialysis, and Transplantation, University of Iowa Stead Family Children's Hospital, Iowa City, IA.
Rationale And Objective: Acute kidney injury (AKI) is a common complication among hospitalized adults, but AKI prediction and prevention among adults has proved challenging. We used machine learning to update the nephrotoxic injury negated by just-in time action (NINJA), a pediatric program that predicts nephrotoxic AKI, to improve accuracy among adults.
Study Design: A retrospective cohort study.
Study of Hydrolysis Kinetics and Synthesis of Single Isomer of Phosphoramidate ProTide-Acyclovir.
ACS Omega
November 2024
Thammasat University Research Unit in Drug, Health Product Development and Application (DHP-DA), Department of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University, Pathum Thani 12120, Thailand.
Article Synopsis
- * Researchers synthesized and separated twelve novel single isomers of ProTide-ACV, finding that certain isomers convert faster during hydrolysis, revealing insights about their metabolic properties.
- * Preliminary tests indicated that three of the isomers had better antiviral effects against HSV-1 than standard acyclovir, underscoring the need for developing pure single isomers for more effective treatments in the future.
Predicting Early Treatment Effectiveness in Bell's Palsy Using Machine Learning: A Focus on Corticosteroids and Antivirals.
Int J Gen Med
November 2024
In-Service Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Article Synopsis
- * Data was collected from 493 patients across 17 hospitals in Scotland, and those were divided into four treatment groups: Prednisolone, Acyclovir, both, and placebo, assessing recovery at 3 and 9 months.
- * Logistic regression emerged as the most accurate model for predicting recovery, emphasizing that younger age and the use of Prednisolone are key factors influencing treatment success.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!