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Genetic susceptibility and potential therapeutic targets of unruptured intracranial aneurysms: A genome-wide study based on Mendelian randomization.
Clin Neurol Neurosurg
January 2025
Department of Interventional Therapy, the First Affiliated Hospital of Dalian Medical University, Dalian, China. Electronic address:
Background: At present, although some studies have offered certain insights into the genetic factors related to unruptured intracranial aneurysms (uIAs), the potential genetic targets associated with uIAs remain largely unknown. Thus, this research adopted Mendelian randomization (MR) analysis to study two genome-wide association studies on uIAs, aiming to determine the reliable genetic susceptibility and potential therapeutic targets for uIAs.
Methods: This study summarizes the data of expression quantitative trait loci (eQTL) as exposure data.
Host size overrides maternal effects on the development of a secondary hyperparasitoid wasp.
J Insect Sci
January 2025
Department of Terrestrial Ecology, Netherlands Institute of Ecology, Wageningen, The Netherlands.
Unraveling the numerous factors that drive phenotypic variation in trait expression among animals has long presented a significant challenge. Whereas traits like growth and adult size are often heritable and are passed on from one generation to the next, these can be significantly affected by the quality and quantity of resources provided by one or both parents to their offspring. In many vertebrates, such as birds and mammals, parents raise their young until adult, providing food, shelter, and protection.
View Article and Find Full Text PDFSickle Cell Anemia and Inflammation: A Review of Stones and Landmarks Paving the Road in the Last 25 Years.
Hematol Rep
January 2025
Laboratory of Immunobiology and Immunogenetics, Post Graduation Program in Genetics and Molecular Biology (PPGBM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre 91501-970, Brazil.
A quarter of a century ago, sickle cell disease (SCD) was mainly viewed as a typical genetic disease inherited as a classical Mendelian trait. Therefore, the main focus concerning SCD was on diagnosis, meaning, genotyping, and identification of homozygous and heterozygous individuals carrying the relevant HbS mutant allele. Nowadays, it is well established that sickle cell disease is indeed the result of homozygosis for the HbS variant, although this single feature is not capable of explaining the highly diverse clinical presentation of SCD.
View Article and Find Full Text PDFImpact of glioma metabolism-related gene ALPK1 on tumor immune heterogeneity and the regulation of the TGF-β pathway.
Front Immunol
January 2025
Department of Neurological Care Unit, The First Affiliated Hospital of YangTze University, Jingzhou, Hubei, China.
Background: Recent years have seen persistently poor prognoses for glioma patients. Therefore, exploring the molecular subtyping of gliomas, identifying novel prognostic biomarkers, and understanding the characteristics of their immune microenvironments are crucial for improving treatment strategies and patient outcomes.
Methods: We integrated glioma datasets from multiple sources, employing Non-negative Matrix Factorization (NMF) to cluster samples and filter for differentially expressed metabolic genes.
Unmasking the Dark Triad: A Data Fusion Machine Learning Approach to Characterize the Neural Bases of Narcissistic, Machiavellian and Psychopathic Traits.
Eur J Neurosci
January 2025
Department of Psychology and Cognitive Sciences (DiPSCo), University of Trento, Trento, Italy.
The Dark Triad (DT), encompassing narcissism, Machiavellianism and psychopathy traits, poses significant societal challenges. Understanding the neural underpinnings of these traits is crucial for developing effective interventions and preventive strategies. Our study aimed to unveil the neural substrates of the DT by examining brain scans from 201 individuals (mean age: 32.
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