After a review of the potential of current methods of investigation and of the slightly modified WHO bone tumor classification, the following neoplastic lesions, the diagnosis and treatment of which still present some unsolved problems, are described in detail: giant cell tumor (osteoclastoma); osteosarcoma, with special reference to malignant osteoblastoma; periosteal osteosarcoma and its disputed relation with or supposed identity to juxtacortical chondrosarcoma; Ewing's sarcoma; and malignant fibrous histiocytoma.
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