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The bioavailability and blood levels of low-dose rapamycin for longevity in real-world cohorts of normative aging individuals.
Geroscience
January 2025
AgelessRx, Ann Arbor, MI, USA.
Rapamycin, also known as sirolimus, has demonstrated great potential for application in longevity medicine. However, the dynamics of low-dose rapamycin bioavailability, and any differences in bioavailability for different formulations (e.g.
View Article and Find Full Text PDFThe development and application of compound formulation of natural antioxidants in maxim. Oil.
Heliyon
January 2025
School of Forestry, Henan Agricultural University, Zhengzhou, 450046, China.
Maxim. is valued for its high oil yield, which fruit has high oil content and good health effects. However, the large amount of unsaturated fatty acids in the oil is easily oxidized, and its storage intolerance has seriously restricted its marketing.
View Article and Find Full Text PDFIntegrating Analytical Procedures in Routine Practices of Centralized Antiblastic Compounding Units for Valorization of Residual Compounded Drugs.
Pharmaceutics
January 2025
Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
Background/objectives: Although extemporaneous formulations of anticancer drug products for personalized therapy are produced according to Good Hospital Pharmacy Manufacturing Practice, the lack of knowledge about drug stability under clinical conditions limits the second-time use of these highly costly medications in clinical practice. Therefore, the residual compounded drugs are considered waste and a cost item that negatively affects the healthcare system. In the context of the ever-increasing interest of the health system in applying practices in line with personalized medicine and spending review policies, this research aimed to demonstrate the feasibility of incorporating analytical techniques into daily routine practice.
View Article and Find Full Text PDFDevelopment of an Adaptable Qualification Test Set for Personnel Involved in Visual Inspection Procedures of Parenteral Drug Products Manufactured Under Good Manufacturing Practice Conditions in Hospital Pharmacy Compounding Facilities.
Pharmaceutics
January 2025
Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen (UMCG), 9713 GZ Groningen, The Netherlands.
Parenteral drug products manufactured under GMP conditions should be visually inspected for defects and particulate contamination by trained and qualified personnel. Although personnel qualification is required, no practical protocols or formal guidelines are available for the development of qualification test sets (QTSs) used for qualification procedures. The current practice is to either procure a standardized QTS from a commercial supplier or amass sufficient manufacturing rejects during visual inspection procedures to compile in-house QTSs.
View Article and Find Full Text PDFA Study on the Mechanism of Cellulose Nanocrystals to Enhance the Stability of Hydrophobic Phthalocyanine Green in Water and the Functional Characteristics of Colour Pastes.
Molecules
January 2025
Plant Fiber Material Science Research Center, State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China.
Cellulose nanocrystals (CNCs) prepared by sulfuric acid hydrolysis were added to phthalocyanine green colour pastes with a surfactant to improve stability. The particle size, zeta potential, absorbance, and microstructure of the colour pastes were analyzed and characterized. The mechanism of CNCs to enhance the stability of hydrophobic phthalocyanine green in water was investigated.
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