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Itsenko-Cushing's disease is a rare, multisystem disease characterized by the presence of endogenous central hypercortisolism due to an ACTH-secreting brain tumor. The frequency of Itsenko-Cushing's disease in adulthood is 0.7-2.
View Article and Find Full Text PDFEndogenous hypercorticism is a severe endocrine disease with clinical symptoms resulting from long-term action of corticosteroids. In this country, conditions caused by the excess pituitary ACTH production are called Itsenko-Cushing disease. In the absence of adequate treatment, half of the patients die within 5 years after the onset of the disease.
View Article and Find Full Text PDFThe effect of different concentrations of N-stearoylethanolamine (NSE 18:0) on fragmentation of DNA in the tumoural and extratumour tissues of the adrenal glands in vitro was studied. In this work the following types of tissue were investigated: extratumoural tissue from patients with hormonally active tumours, benign tumour tissue (hormonally active and hormonally inactive), tissue of malignant tumours and hyperplasic tissue of the adrenal glands (Itsenko-Cushing disease). It has been established that the NSE increases the intensity of DNA fragmentation only in the tissue of hormonally inactive tumours.
View Article and Find Full Text PDFInternucleosomal fragmentation of DNA that was isolated from the extratumour tissue of patients with hormonally active and inactive tumors, the tissues of hormonally active and inactive tumors, and also the hyperplastic adrenal tissue in patients with Itsenko-Cushing disease was studied in agarose gel using the method of electrophoresis. It has been established that the intensity of DNA fragmentation in hormonally inactive tumours did not differ from the tissue that was surrounding such tumours, and only a decrease in the mononucleosome level was revealed. The increased level of oligonucleosomas with the size of 200-800 p.
View Article and Find Full Text PDF[Problem aspects of diagnostics and surgical treatment of Itsenko-Cushing syndrome].
Vestn Khir Im I I Grek
January 2011
The author has analyzed results of examination and treatment of 142 patients with Itsenko-Cushing syndrome. It was established that careful observation of the diagnostic algorithm (estimation of the blood cortisol, adrenocorticotropic hormone level, tests with 8 mg dexamethasone, MRI of adrenal glands and hypophysis with obligatory using contrast paramagnetic substances) allowed differentiation of basic forms of endogenous hypercorticalism: Itsenko-Cushing disease in 83.1%, cortisol-productive adenoma cases in 16.
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