Rat tail muscle responses decreased in amplitude and showed polyphasia in intermittent (3 h daily for 4 to 8 wks) percutaneous exposure to a commercial terphenyl mixture. The gross conduction times did not change excluding demyelination as a mechanism. The exposure technique allowed an exact estimation of the absorbed dose (0.23 +/- 0.05 g/12 cm2 skin in 3 h). This could be altered by changing the skin contact time. The described technique may used also in the detection of local toxicity of other lipid-soluble compounds.
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