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Fibroblast Growth Factor 8 enhances the chondrogenesis of trunk neural crest cells: a possible gene regulatory network.
Int J Dev Biol
December 2024
Laboratory of Plasticity and Differentiation of Neural Crest Cells, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.
The neural crest (NC) is an embryonic cell population with high migratory capacity. It contributes to forming several organs and tissues, such as the craniofacial skeleton and the peripheral nervous system of vertebrates. Both pre-migratory and post-migratory NC cells are plastic, adopting multiple differentiation paths by responding to different inductive environmental signals.
View Article and Find Full Text PDFThe bone Gla protein osteocalcin is expressed in cranial neural crest cells.
BMC Res Notes
November 2024
Koret School of Veterinary Medicine, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University, Rehovot, 76100, Israel.
Background: Osteocalcin is a small protein abundant in the bone extracellular-matrix, that serves as a marker for mature osteoblasts. To become activated, osteocalcin undergoes a specific post-translational carboxylation. Osteocalcin is expressed at advanced stages of embryogenesis and after birth, when bone formation takes place.
View Article and Find Full Text PDFCraniofacial studies in chicken embryos confirm the pathogenicity of human FZD2 variants associated with Robinow syndrome.
Dis Model Mech
June 2024
Life Sciences Institute and Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
Robinow syndrome is a rare disease caused by variants of seven WNT pathway genes. Craniofacial features include widening of the nasal bridge and jaw hypoplasia. We used the chicken embryo to test whether two missense human FZD2 variants (1301G>T, p.
View Article and Find Full Text PDFInfluence of DNA-methylation at multiple stages of limb chondrogenesis.
Dev Biol
August 2024
Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Apartado Postal 70228, Ciudad de México, 04510, México. Electronic address:
Article Synopsis
- Precise gene expression regulation is essential for determining cell fate, with DNA methylation acting as a key player by managing how genes are turned on or off during this process.
- Limb development serves as a model for studying these cell fate decisions, especially in cartilage formation, although its early stages need more exploration regarding epigenetic controls.
- This study reveals that disrupting DNA methylation in limb tissues can lead to abnormal digit formation, highlighting its vital role in cell fate determination during early chondrogenesis.
Isolation and Micromass Culturing of Primary Chicken Chondroprogenitor Cells for Cartilage Regeneration.
Curr Protoc
July 2023
Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Article Synopsis
- Much of the skeletal system develops through endochondral ossification, particularly in early fetal life, making it difficult to study initial chondrogenesis in living organisms.
- Researchers are highly interested in improving methods for culturing chondrogenic cells to effectively regenerate articular cartilage and restore joint function.
- The article outlines various protocols, including a micromass culture system for chick embryo-derived cells, high-efficiency cell transfection, and histochemical detection techniques for assessing cartilage matrix production.
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