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An analysis of the clinical significance of the TKI-resistant gene ZNF687 for hepatocellular carcinoma patients.
Adv Clin Exp Med
October 2024
Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Article Synopsis
- Novel treatments have improved survival rates for hepatocellular carcinoma (HCC) patients, but resistance to these therapies is a key challenge, highlighting the need for research into drug resistance mechanisms.
- The study focuses on the tyrosine kinase inhibitor (TKI)-resistant gene ZNF687, examining its role and clinical significance in HCC through various bioinformatics and molecular analysis techniques.
- Results indicate that ZNF687 is overexpressed in HCC and linked to poorer patient outcomes, with histone modification and related pathways identified as significant, alongside the compound chaetocin showing potential against ZNF687.
Released bacterial ATP shapes local and systemic inflammation during abdominal sepsis.
Elife
August 2024
Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University Hospital of Bern, Bern, Switzerland.
Sepsis causes millions of deaths per year worldwide and is a current global health priority declared by the WHO. Sepsis-related deaths are a result of dysregulated inflammatory immune responses indicating the need to develop strategies to target inflammation. An important mediator of inflammation is extracellular adenosine triphosphate (ATP) that is released by inflamed host cells and tissues, and also by bacteria in a strain-specific and growth-dependent manner.
View Article and Find Full Text PDFThermal stress and selection for growth affect myogenic satellite cell lipid accumulation and adipogenic gene expression through mechanistic target of rapamycin pathway.
J Anim Sci
August 2022
Department of Animal Sciences, The Ohio State University, Wooster, OH, USA.
Satellite cells (SCs) are multipotential stem cells having the plasticity to convert to an adipogenic lineage in response to thermal stress during the period of peak mitotic activity (the first week after hatch in poultry). The mechanistic target of rapamycin (mTOR) pathway, which regulates cellular function and fate of SCs, is greatly altered by thermal stress in turkey pectoralis major muscle SCs. The objective of the present study was to determine the effects of thermal stress, selection for growth, and the role of the mTOR pathway on SC intracellular lipid accumulation and expression of adipogenic regulatory genes.
View Article and Find Full Text PDFDifferential efficacy of water lily cultivars in phytoremediation of eutrophic water contaminated with phosphorus and nitrogen.
Plant Physiol Biochem
January 2022
College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, 210095, China.
Excessive inputs of phosphorus (P) and nitrogen (N) trigger eutrophication of the water bodies, which promotes the undesirable growth of algal bloom and deterioration of the water quality, and aquatic biodiversity. Macrophytes provide an environmentally benign and economically viable paradigm for the ecological restoration of eutrophic aquatic ecosystems. Water lily (Nymphaea) is largely used as ornamental plant for landscaping, and it has been documented that water lily possesses the potentiality in mitigating polluted aquatic environments.
View Article and Find Full Text PDFGrowth-Dependent Activation of Protein Kinases Suggests a Mechanism for Measuring Cell Growth.
Genetics
July 2020
Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, California 95064
In all cells, progression through the cell cycle occurs only when sufficient growth has occurred. Thus, cells must translate growth into a proportional signal that can be used to measure and transmit information about growth. Previous genetic studies in budding yeast suggested that related kinases called Gin4 and Hsl1 could function in mechanisms that measure bud growth; however, interpretation of the data was complicated by the use of gene deletions that cause complex terminal phenotypes.
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