AI Article Synopsis
- The study examined bioptic specimens from the lower duodenum of 12 volunteers to measure the activity of four specific enzymes at various times throughout the day.
- Alkaline phosphatase and acid phosphatase showed peak activity in the morning (06h), while 5' nucleotidase reached its highest level in the afternoon (14h), and NADPH was most active in the evening (18h).
- The findings suggest that human intestinal function exhibits a circadian rhythm similar to that observed in animals.
Article Abstract
Bioptic specimens taken from the lower duodenum were studied in 12 volunteers at different times of the day for the activity of 4 marker enzymes. The activity of alkaline phosphatase in brush border of villi was the strongest at 06h, while the nadir at 22h; acid phosphatase activity in the supranuclear zone and in macrophages was the strongest at 06h and reduced at other test times; the peak activity of 5' nucleotidase was found at 14h with the nadir at 02h; activity of NADPH was the strongest at 18h. It is suggested that circadian rhythmicity of intestinal function exists in man like in animals.
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| http://dx.doi.org/10.1016/s0065-1281(83)80015-4 | DOI Listing |
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