Sjögren syndrome, characterized by lymphocytic proliferation and drying up of exocrine secretions ("sicca syndrome") due to glandular destruction, is well known for it's ocular and salivary localizations. However, other glandular epithelia (bronchial, vaginal . . .) or parenchyma (such as the kidney) may be involved. Damage to the kidney is rarely prominent; it is usually discovered late in the course of the disease. Moreover the renal manifestations are multiple and variably associated: diabetes insipidus, tubular acidosis, Fanconi syndrome, tubular and interstitial nephritis, and glomerulonephritis.
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